Reactome | C2CD3 binds the mother centriole

C2CD3 binds the mother centriole

Stable Identifier

R-HSA-5626220

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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C2 domain-containing protein 3 (C2CD3) is basal body-localized protein that is required for ciliogenesis and Hh signaling (Hoover et al, 2008; Balestra et al, 2013). C2CD3 is recruited to the centrosome in a pericentriolar material 1 protein (PCM1)- and microtubule-dependent manner and is required for the subsequent recruitment of the distal appendage proteins to the mother centriole (Tanos et al, 2013; Sillibourne et al, 2013; Ye et al, 2014; reviewed in Winey and O'Toole, 2014). The distal appendage proteins are thought to be a component of the transition fibres that anchor the basal body to the membrane at the base of the cilium and are themselves required for the recruitment of Tau-tubulin kinase 2 (TTBK2) and for docking ciliary vesicles to the mother centriole (Tanos et al, 2013; Wei et al, 2013; Joo et al, 2013; Schmidt et al, 2012; Sillibourne et al, 2013; Burke et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
25313408	Chibby promotes ciliary vesicle formation and basal body docking during airway cell differentiation Kuriyama, R, Cyge, B, Weiss, MA, Brechbuhl, HM, Burke, MC, Siller, SS, Chen, X, Reynolds, SD, Westlake, CJ, Arashiro, T, O'Connell, CB, Takemaru, K, Li, FQ, Love, D	J. Cell Biol.	2014
24469809	C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals Zeng, H, Ning, G, Liu, A, Reiter, JF, Ye, X	Proc. Natl. Acad. Sci. U.S.A.	2014
23253480	Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis Hub, B, Neuner, A, Zentgraf, H, Kuhns, S, Schmidt, KN, Pereira, G	J. Cell Biol.	2012
23769972	Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells Balestra, FR, Flückiger, I, Gönczy, P, Strnad, P	Dev. Cell	2013
23348840	Centriole distal appendages promote membrane docking, leading to cilia initiation Tanos, BE, Soni, R, Wang, WJ, Tsou, MF, Macaluso, FP, Asara, JM, Yang, HJ	Genes Dev.	2013
19004860	C2cd3 is required for cilia formation and Hedgehog signaling in mouse Niswander, LA, Zeng, H, Liu, A, Jia, J, Hoover, AN, Wynkoop, A	Development	2008
23530209	CCDC41 is required for ciliary vesicle docking to the mother centriole Kim, J, Kim, CH, Park, WY, Kim, CG, Gleeson, JG, Kweon, HS, Kim, MJ, Lee, SH, Lee, MS, Moon, HY, Joo, K	Proc. Natl. Acad. Sci. U.S.A.	2013
25047611	Centriole structure O'Toole, E, Winey, M	Philos. Trans. R. Soc. Lond., B, Biol. Sci.	2014
19940019	Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling Hall, J, Mofunanya, A, Fischer, V, Takemaru, K, Li, FQ	Mol. Biol. Cell	2010
23789104	Primary ciliogenesis requires the distal appendage component Cep123 Tran, P, Hurbain, I, Grand-Perret, T, Goud, B, Bornens, M, Sillibourne, JE	Biol Open	2013
24231678	Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes Torres, VE, Hu, Z, Ling, K, Wei, Q, Hu, J, Zhang, Q, Li, Y, Zhang, Y, Harris, PC, Xu, Q	Nat Commun	2013