RHO GTPases activate KTN1

Stable Identifier
R-HSA-5625970
Type
Pathway
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RHO GTPases activate KTN1
Click the image above or here to open this pathway in the Pathway Browser

GTP-bound active forms of RHO GTPases RHOA, RHOG, RAC1 and CDC42 bind kinectin (KTN1), a protein inserted in endoplasmic reticulum membranes that interacts with the cargo-binding site of kinesin and activates its microtubule-stimulated ATPase activity required for vesicle motility (Vignal et al. 2001, Hotta et al. 1996). The effect of RHOG activity on cellular morphology, exhibited in the formation of microtubule-dependent cellular protrusions, depends both on RHOG interaction with KTN1, as well as on the kinesin activity (Vignal et al. 2001). RHOG and KTN1 also cooperate in microtubule-dependent lysosomal transport (Vignal et al. 2001). The precise mechanism of kinectin-mediated Rho GTPase signaling cascade needs further elucidation, and only the first two steps, KTN1-activated RHO GTPase binding, and KTN1-kinesin-1 binding are annotated here.

Literature References
PubMed ID Title Journal Year
8769096 Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor

Hotta, K, Tanaka, K, Mino, A, Kohno, H, Takai, Y

Biochem. Biophys. Res. Commun. 1996
11689693 Kinectin is a key effector of RhoG microtubule-dependent cellular activity

Vignal, E, Blangy, A, Martin, M, Gauthier-Rouvière, C, Fort, P

Mol. Cell. Biol. 2001
Participants
Events
Participant Of
hasEvent
Orthologous Events
RHO GTPases activate KTN1 (Bos taurus)
RHO GTPases activate KTN1 (Canis familiaris)
RHO GTPases activate KTN1 (Danio rerio)
RHO GTPases activate KTN1 (Mus musculus)
RHO GTPases activate KTN1 (Rattus norvegicus)
RHO GTPases activate KTN1 (Sus scrofa)
RHO GTPases activate KTN1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2014-10-09)