Reactome | Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)

Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)

Stable Identifier

R-HSA-5625959

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)

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Kinectin, a kinesin anchor involved in kinesin-mediated vesicle motility, interacts with GTP bound (active) forms of Rho GTPases RHOG (Vignal et al. 2001), RHOA, RAC1 and CDC42 (Hotta et al. 1996). Separate domains of kinectin are responsible for its interaction with RHOG and RHOA (Vignal et al. 2001). Based on several studies in different organisms, kinectin likely exists as a coiled-coil dimer (Yu et al. 1995, Leung et al. 1996, Kumar et al. 1998, Xu et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
9822636	Ultrastructural and biochemical properties of the 120-kDa form of chick kinectin Erickson, HP, Sheetz, MP, Kumar, J	J. Biol. Chem.	1998
11933159	Molecular cloning and characterization of fox testis kinectin Bradley, MP, Janssens, PA, Xu, J, Hardy, CM, Bird, PH	Mol. Reprod. Dev.	2002
8912005	Cloning of novel kinectin splice variants with alternative C-termini: structure, distribution and evolution of mouse kinectin Print, CG, Krissansen, GW, Parry, DA, Closey, DN, Skinner, SJ, Batchelor, DC, Leung, E, Lockhart, PJ	Immunol. Cell Biol.	1996
7787244	Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis Becker, M, Toyoshima, I, Yu, H, Sheetz, MP, Kumar, J, Nicchitta, CV	Mol. Biol. Cell	1995
11689693	Kinectin is a key effector of RhoG microtubule-dependent cellular activity Blangy, A, Gauthier-Rouvière, C, Vignal, E, Martin, M, Fort, P	Mol. Cell. Biol.	2001
8769096	Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor Mino, A, Kohno, H, Hotta, K, Takai, Y, Tanaka, K	Biochem. Biophys. Res. Commun.	1996