Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)

Stable Identifier
R-HSA-5625959
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Kinectin, a kinesin anchor involved in kinesin-mediated vesicle motility, interacts with GTP bound (active) forms of Rho GTPases RHOG (Vignal et al. 2001), RHOA, RAC1 and CDC42 (Hotta et al. 1996). Separate domains of kinectin are responsible for its interaction with RHOG and RHOA (Vignal et al. 2001). Based on several studies in different organisms, kinectin likely exists as a coiled-coil dimer (Yu et al. 1995, Leung et al. 1996, Kumar et al. 1998, Xu et al. 2002).

Literature References
PubMed ID Title Journal Year
11933159 Molecular cloning and characterization of fox testis kinectin

Xu, J, Bird, PH, Bradley, MP, Janssens, PA, Hardy, CM

Mol. Reprod. Dev. 2002
9822636 Ultrastructural and biochemical properties of the 120-kDa form of chick kinectin

Kumar, J, Erickson, HP, Sheetz, MP

J. Biol. Chem. 1998
8912005 Cloning of novel kinectin splice variants with alternative C-termini: structure, distribution and evolution of mouse kinectin

Leung, E, Print, CG, Parry, DA, Closey, DN, Lockhart, PJ, Skinner, SJ, Batchelor, DC, Krissansen, GW

Immunol. Cell Biol. 1996
7787244 Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis

Yu, H, Nicchitta, CV, Kumar, J, Becker, M, Toyoshima, I, Sheetz, MP

Mol. Biol. Cell 1995
11689693 Kinectin is a key effector of RhoG microtubule-dependent cellular activity

Vignal, E, Blangy, A, Martin, M, Gauthier-Rouvière, C, Fort, P

Mol. Cell. Biol. 2001
8769096 Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor

Hotta, K, Tanaka, K, Mino, A, Kohno, H, Takai, Y

Biochem. Biophys. Res. Commun. 1996
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