Reactome | PKN1 in complex with AR positively regulates expression of KLK2 and KLK3

PKN1 in complex with AR positively regulates expression of KLK2 and KLK3

Stable Identifier

R-HSA-5625883

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

extracellular region, nucleoplasm

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate PKNs (Homo sapiens)
        
        Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
        
        PKN1 in complex with AR positively regulates expression of KLK2 and KLK3 (Homo sapiens)

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PKN1 in complex with AR positively regulates expression of KLK2 and KLK3

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PKN1-facilitated demethylation of histones at promoters of KLK2 and KLK3 genes stimulates transcription of KLK2 and KLK3 (Metzger et al. 2005, Metzger et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18066052	Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation Kunowska, N, Patnaik, D, Schüle, R, Metzger, E, Wissmann, M, Potier, N, Scheidtmann, KH, Higgins, JM, Friedrichs, N, Buettner, R, Fischer, K, Yin, N	Nat. Cell Biol.	2008