KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters

Stable Identifier
R-HSA-5625797
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters
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KDM4C (JMJD2C) demethylates trimethylated lysine K10 of histone 3 in nucleosomes associated with promoters of KLK2 and KLK3 (PSA) genes (Metzger et al. 2008), converting it to dimethylated lysine (Whetstine et al. 2006).
Literature References
PubMed ID Title Journal Year
18066052 Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation

Kunowska, N, Patnaik, D, Schüle, R, Metzger, E, Wissmann, M, Potier, N, Scheidtmann, KH, Higgins, JM, Friedrichs, N, Buettner, R, Fischer, K, Yin, N

Nat. Cell Biol. 2008
16603238 Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

Spooner, E, Smolikov, S, Shi, Y, Lan, F, Chen, Z, Zhang, G, Li, E, Huarte, M, Colaiácovo, MP, Nottke, A, Whetstine, JR

Cell 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

histone demethylase activity of p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm]

Physical Entity
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Homo sapiens)
Activity
histone demethylase activity (GO:0032452)
Orthologous Events
KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Bos taurus)
KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Canis familiaris)
KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Danio rerio)
KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Drosophila melanogaster)
KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Gallus gallus)
KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Rattus norvegicus)
KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Saccharomyces cerevisiae)
KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Sus scrofa)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2014-10-07)
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