Reactome | KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters

KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters

Stable Identifier

R-HSA-5625797

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate PKNs (Homo sapiens)
        
        Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
        
        KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Homo sapiens)

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KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters

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KDM4C (JMJD2C) demethylates trimethylated lysine K10 of histone 3 in nucleosomes associated with promoters of KLK2 and KLK3 (PSA) genes (Metzger et al. 2008), converting it to dimethylated lysine (Whetstine et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
18066052	Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation Metzger, E, Yin, N, Wissmann, M, Kunowska, N, Fischer, K, Friedrichs, N, Patnaik, D, Higgins, JM, Potier, N, Scheidtmann, KH, Buettner, R, Schüle, R	Nat. Cell Biol.	2008
16603238	Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases Whetstine, JR, Nottke, A, Lan, F, Huarte, M, Smolikov, S, Chen, Z, Spooner, E, Li, E, Zhang, G, Colaiácovo, MP, Shi, Y	Cell	2006