Demethylase KDM4C binds KLK2 and KLK3 promoters

Stable Identifier
R-HSA-5625796
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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Demethylase KDM4C binds KLK2 and KLK3 promoters
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Phosphorylation of histone 3 at threonine residue T12 (also labeled in literature as T11) by PKN1 enables recruitment of demethylase KDM4C (JMJD2C) to trimethylated histone 3 at KLK2 and KLK3 promoters (Metzger et al. 2008). KDM4C specifically binds to trimethylated lysine residues (Whetstine et al. 2006).

Literature References
PubMed ID Title Journal Year
16603238 Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

Whetstine, JR, Nottke, A, Lan, F, Huarte, M, Smolikov, S, Chen, Z, Spooner, E, Li, E, Zhang, G, Colaiácovo, MP, Shi, Y

Cell 2006
18066052 Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation

Metzger, E, Yin, N, Wissmann, M, Kunowska, N, Fischer, K, Friedrichs, N, Patnaik, D, Higgins, JM, Potier, N, Scheidtmann, KH, Buettner, R, Schüle, R

Nat. Cell Biol. 2008
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Orthologous Events
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Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2014-10-07)