Reactome | Demethylase KDM4C binds KLK2 and KLK3 promoters

Demethylase KDM4C binds KLK2 and KLK3 promoters

Stable Identifier

R-HSA-5625796

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

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Demethylase KDM4C binds KLK2 and KLK3 promoters

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Phosphorylation of histone 3 at threonine residue T12 (also labeled in literature as T11) by PKN1 enables recruitment of demethylase KDM4C (JMJD2C) to trimethylated histone 3 at KLK2 and KLK3 promoters (Metzger et al. 2008). KDM4C specifically binds to trimethylated lysine residues (Whetstine et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16603238	Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases Whetstine, JR, Nottke, A, Lan, F, Huarte, M, Smolikov, S, Chen, Z, Spooner, E, Li, E, Zhang, G, Colaiácovo, MP, Shi, Y	Cell	2006
18066052	Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation Metzger, E, Yin, N, Wissmann, M, Kunowska, N, Fischer, K, Friedrichs, N, Patnaik, D, Higgins, JM, Potier, N, Scheidtmann, KH, Buettner, R, Schüle, R	Nat. Cell Biol.	2008