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Nucleosome with H3K9me3 [nucleoplasm]
Stable Identifier
R-HSA-5625748
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nucleosome with Deacetylated H4 and H3 Trimethylated at Lysine-9
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by KRAB-ZFP proteins (Homo sapiens)
SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes (Homo sapiens)
ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin with H3K9me3 [nucleoplasm] (Homo sapiens)
KRAB-ZFP:retroelement chromatin with H3K9me3 [nucleoplasm] (Homo sapiens)
Retroelement chromatin with H3K9me3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex (Homo sapiens)
MPHOSPH8 (MPP8) in HUSH complex binds histone H3 trimethyl-lysine 9 (H3K9me3) in L1HS,L1PA2,3 heterochromatin (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
L1HS,L1PA2,3:Nucleosome with H2K9me3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
L1HS,L1PA2,3:Nucleosome with H2K9me3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
MPHOSPH8 of the HUSH complex bound to retroelement chromatin binds ZCCHC8 of the NEXT complex (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
L1HS,L1PA2,3:Nucleosome with H2K9me3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
NEXT complex:HUSH complex:L1HS:L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
L1HS,L1PA2,3:Nucleosome with H2K9me3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
L1HS,L1PA2,3:Nucleosome with H2K9me3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1HS,L1PA2,3 heterochromatin (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
L1HS,L1PA2,3:Nucleosome with H2K9me3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
L1HS,L1PA2,3:Nucleosome with H2K9me3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Homo sapiens)
KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Homo sapiens)
KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Homo sapiens)
KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Homo sapiens)
KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Homo sapiens)
KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Homo sapiens)
KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Homo sapiens)
KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
Participants
components
x 2
H3K9me3 [nucleoplasm]
(Homo sapiens)
x 2
HIST1H4 [nucleoplasm]
(Homo sapiens)
x 2
Histone H2A [nucleoplasm]
(Homo sapiens)
x 2
Histone H2B [nucleoplasm]
(Homo sapiens)
Participates
as a component of
KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Homo sapiens)
L1HS,L1PA2,3:Nucleosome with H2K9me3 [nucleoplasm] (Homo sapiens)
Retroelement chromatin with H3K9me3 [nucleoplasm] (Homo sapiens)
KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Homo sapiens)
as an output of
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome (Homo sapiens)
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) (Homo sapiens)
Inferred To
Nucleosome with H3K9me3 [nucleoplasm]
(Bos taurus)
Nucleosome with H3K9me3 [nucleoplasm]
(Caenorhabditis elegans)
Nucleosome with H3K9me3 [nucleoplasm]
(Canis familiaris)
Nucleosome with H3K9me3 [nucleoplasm]
(Danio rerio)
Nucleosome with H3K9me3 [nucleoplasm]
(Dictyostelium discoideum)
Nucleosome with H3K9me3 [nucleoplasm]
(Drosophila melanogaster)
Nucleosome with H3K9me3 [nucleoplasm]
(Gallus gallus)
Nucleosome with H3K9me3 [nucleoplasm]
(Mus musculus)
Nucleosome with H3K9me3 [nucleoplasm]
(Plasmodium falciparum)
Nucleosome with H3K9me3 [nucleoplasm]
(Rattus norvegicus)
Nucleosome with H3K9me3 [nucleoplasm]
(Saccharomyces cerevisiae)
Nucleosome with H3K9me3 [nucleoplasm]
(Schizosaccharomyces pombe)
Nucleosome with H3K9me3 [nucleoplasm]
(Sus scrofa)
Nucleosome with H3K9me3 [nucleoplasm]
(Xenopus tropicalis)
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