The anterograde IFT train dissociates

Stable Identifier
R-HSA-5625421
Type
Reaction
Species
Homo sapiens
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Based on work done in C. reinhardtii and Trypanosoma brucei, anterograde IFT trains are believed to disassemble at the ciliary tip, releasing cargo and the IFT motors. Smaller retrograde trains are subsequently reassembled for transport back to the ciliary base (Iomini et al, 2001; Buisson et al, 2013; Pigino et al, 2009; reviewed in Ishikawa et al, 2011; Bhogaraju et al, 2013). A direct interaction between IFT27 and the nucleotide-free form of ARL6 may contribute to ARL6 activation and in this way contribute to ciliary exit of some cargo (Liew et al, 2014).

Literature References
PubMed ID Title Journal Year
19805633 Electron-tomographic analysis of intraflagellar transport particle trains in situ

Pigino, G, Geimer, S, Lanzavecchia, S, Paccagnini, E, Cantele, F, Diener, DR, Rosenbaum, JL, Lupetti, P

J. Cell Biol. 2009
21427764 Ciliogenesis: building the cell's antenna

Ishikawa, H, Marshall, WF

Nat. Rev. Mol. Cell Biol. 2011
11285270 Protein particles in Chlamydomonas flagella undergo a transport cycle consisting of four phases

Iomini, C, Babaev-Khaimov, V, Sassaroli, M, Piperno, G

J. Cell Biol. 2001
25443296 The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3

Liew, G M, Ye, F, Nager, A R, Murphy, J P, Lee, J S, Aguiar, M, Breslow, DK, Gygi, S, Nachury, MV

DevCell 2014
23945166 Intraflagellar transport complex structure and cargo interactions

Bhogaraju, S, Engel, BD, Lorentzen, E

Cilia 2013
22992454 Intraflagellar transport proteins cycle between the flagellum and its base

Buisson, J, Chenouard, N, Lagache, T, Blisnick, T, Olivo-Marin, JC, Bastin, P

J. Cell. Sci. 2013
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