Based on work done in C. reinhardtii and Trypanosoma brucei, anterograde IFT trains are believed to disassemble at the ciliary tip, releasing cargo and the IFT motors. Smaller retrograde trains are subsequently reassembled for transport back to the ciliary base (Iomini et al, 2001; Buisson et al, 2013; Pigino et al, 2009; reviewed in Ishikawa et al, 2011; Bhogaraju et al, 2013). A direct interaction between IFT27 and the nucleotide-free form of ARL6 may contribute to ARL6 activation and in this way contribute to ciliary exit of some cargo (Liew et al, 2014).
Ishikawa, H, Marshall, WF
Pigino, G, Lanzavecchia, S, Lupetti, P, Geimer, S, Diener, DR, Paccagnini, E, Rosenbaum, JL, Cantele, F
Babaev-Khaimov, V, Piperno, G, Iomini, C, Sassaroli, M
Ye, F, Aguiar, M, Nager, A R, Gygi, S, Murphy, J P, Liew, G M, Lee, J S, Nachury, MV, Breslow, DK
Bhogaraju, S, Engel, BD, Lorentzen, E
Blisnick, T, Buisson, J, Bastin, P, Olivo-Marin, JC, Lagache, T, Chenouard, N
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