Reactome | The anterograde IFT train dissociates

The anterograde IFT train dissociates

Stable Identifier

R-HSA-5625421

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cilium

ReviewStatus

5/5

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Based on work done in C. reinhardtii and Trypanosoma brucei, anterograde IFT trains are believed to disassemble at the ciliary tip, releasing cargo and the IFT motors. Smaller retrograde trains are subsequently reassembled for transport back to the ciliary base (Iomini et al, 2001; Buisson et al, 2013; Pigino et al, 2009; reviewed in Ishikawa et al, 2011; Bhogaraju et al, 2013). A direct interaction between IFT27 and the nucleotide-free form of ARL6 may contribute to ARL6 activation and in this way contribute to ciliary exit of some cargo (Liew et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
21427764	Ciliogenesis: building the cell's antenna Ishikawa, H, Marshall, WF	Nat. Rev. Mol. Cell Biol.	2011
19805633	Electron-tomographic analysis of intraflagellar transport particle trains in situ Pigino, G, Lanzavecchia, S, Lupetti, P, Geimer, S, Diener, DR, Paccagnini, E, Rosenbaum, JL, Cantele, F	J. Cell Biol.	2009
11285270	Protein particles in Chlamydomonas flagella undergo a transport cycle consisting of four phases Babaev-Khaimov, V, Piperno, G, Iomini, C, Sassaroli, M	J. Cell Biol.	2001
25443296	The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3 Ye, F, Aguiar, M, Nager, A R, Gygi, S, Murphy, J P, Liew, G M, Lee, J S, Nachury, MV, Breslow, DK	DevCell	2014
23945166	Intraflagellar transport complex structure and cargo interactions Bhogaraju, S, Engel, BD, Lorentzen, E	Cilia	2013
22992454	Intraflagellar transport proteins cycle between the flagellum and its base Blisnick, T, Buisson, J, Bastin, P, Olivo-Marin, JC, Lagache, T, Chenouard, N	J. Cell. Sci.	2013