Anterograde IFT

Stable Identifier
R-HSA-5625416
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
Anterograde IFT trains translocate from the ciliary base to the ciliary tip
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Anterograde trains travel along the axoneme of the cilium at an estimated rate of 2 micrometers per second in an ATP- and kinesin-2-dependent fashion (reviewed in Cole and Snell, 2009). Although the particulars of IFT train-cargo interactions have not been fully elaborated, recent studies in C. reinhardtii and human cells have shown that the IFT B components IFT74 and IFT81 have tubulin-binding sites, while IFT46 is required for the ciliary transport of the outer dynein arm, and more recently, TTC26 has been shown to be required for the transport of motility-related proteins into the flagella (Bhogaraju et al, 2013; Ahmed et al, 2008; Hou et al, 2007; Ishikawa et al, 2014; reviewed in Bhogarju et al, 2014).

Literature References
PubMed ID Title Journal Year
19450523 SnapShot: Intraflagellar transport

Cole, DG, Snell, WJ

Cell 2009
17312020 Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella

Hou, Y, Qin, H, Follit, JA, Pazour, GJ, Rosenbaum, JL, Witman, GB

J. Cell Biol. 2007
23990561 Molecular basis of tubulin transport within the cilium by IFT74 and IFT81

Bhogaraju, S, Cajanek, L, Fort, C, Blisnick, T, Weber, K, Taschner, M, Mizuno, N, Lamla, S, Bastin, P, Nigg, EA, Lorentzen, E

Science 2013
18852297 ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery

Ahmed, NT, Gao, C, Lucker, BF, Cole, DG, Mitchell, DR

J. Cell Biol. 2008
24596149 TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella

Ishikawa, H, Ide, T, Yagi, T, Jiang, X, Hirono, M, Sasaki, H, Yanagisawa, H, Wemmer, KA, Stainier, DY, Qin, H, Kamiya, R, Marshall, WF

Elife 2014
24616010 Getting tubulin to the tip of the cilium: one IFT train, many different tubulin cargo-binding sites?

Bhogaraju, S, Weber, K, Engel, BD, Lechtreck, KF, Lorentzen, E

Bioessays 2014
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