Reactome | Assembly of the retrograde IFT train

Assembly of the retrograde IFT train

Stable Identifier

R-HSA-5624952

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cilium

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Remodelling of IFT trains is thought to occur at the ciliary tip (Iomini et al, 2001; Buisson et al, 2013; reviewed in Snell and Cole, 2009). Retrograde transport is driven by the multi-subunit dynein-2 motor in an ATP-dependent fashion (Hou et al, 2004; Pazour et al, 1999; Porter et al, 1999; reviewed in Cole and Snell, 2009; Ishikawa et al, 2011). Mutations in genes encoding members of the IFT A complex or the dynein-2 motor generally result in short, swollen cilia that abnormally accumulate IFT components (Iomini et al, 2009; Piperno et al, 1998; Pazour et al, 1999). The subunit composition of the human dynein-2 complex has recently been analyzed and preliminary characterization of the IFT A complex has begun, but detailed understanding of the molecular architecture of the retrograde IFT trains is still lacking (Assante et al, 2014; Piperno et al, 1998; Mukhopadhyay et al, 2010; reviewed in Taschner et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
21427764	Ciliogenesis: building the cell's antenna Ishikawa, H, Marshall, WF	Nat. Rev. Mol. Cell Biol.	2011
15269286	A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar transport Hou, Y, Pazour, GJ, Witman, GB	Mol. Biol. Cell	2004
19450523	SnapShot: Intraflagellar transport Cole, DG, Snell, WJ	Cell	2009
9585416	A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT) Pazour, GJ, Wilkerson, CG, Witman, GB	J. Cell Biol.	1998
11285270	Protein particles in Chlamydomonas flagella undergo a transport cycle consisting of four phases Iomini, C, Babaev-Khaimov, V, Sassaroli, M, Piperno, G	J. Cell Biol.	2001
9852153	Distinct mutants of retrograde intraflagellar transport (IFT) share similar morphological and molecular defects Piperno, G, Siuda, E, Henderson, S, Segil, M, Vaananen, H, Sassaroli, M	J. Cell Biol.	1998
19720863	Retrograde intraflagellar transport mutants identify complex A proteins with multiple genetic interactions in Chlamydomonas reinhardtii Iomini, C, Li, L, Esparza, JM, Dutcher, SK	Genetics	2009
10069812	Cytoplasmic dynein heavy chain 1b is required for flagellar assembly in Chlamydomonas Porter, ME, Bower, R, Knott, JA, Byrd, P, Dentler, W	Mol. Biol. Cell	1999
20889716	TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia Mukhopadhyay, S, Wen, X, Chih, B, Nelson, CD, Lane, WS, Scales, SJ, Jackson, PK	Genes Dev.	2010
22992454	Intraflagellar transport proteins cycle between the flagellum and its base Buisson, J, Chenouard, N, Lagache, T, Blisnick, T, Olivo-Marin, JC, Bastin, P	J. Cell. Sci.	2013
25205765	Subunit composition of the human cytoplasmic dynein-2 complex Asante, D, Stevenson, NL, Stephens, DJ	J. Cell. Sci.	2014
22118932	Architecture and function of IFT complex proteins in ciliogenesis Taschner, M, Bhogaraju, S, Lorentzen, E	Differentiation	2012