Assembly of the retrograde IFT train

Stable Identifier
R-HSA-5624952
Type
Reaction [binding]
Species
Homo sapiens
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Remodelling of IFT trains is thought to occur at the ciliary tip (Iomini et al, 2001; Buisson et al, 2013; reviewed in Snell and Cole, 2009). Retrograde transport is driven by the multi-subunit dynein-2 motor in an ATP-dependent fashion (Hou et al, 2004; Pazour et al, 1999; Porter et al, 1999; reviewed in Cole and Snell, 2009; Ishikawa et al, 2011). Mutations in genes encoding members of the IFT A complex or the dynein-2 motor generally result in short, swollen cilia that abnormally acccumulate IFT components (Iomini et al, 2009; Piperno et al, 1998; Pazour et al, 1999). The subunit composition of the human dynein-2 complex has recently been analyzed and preliminary characterization of the IFT A complex has begun, but detailed understanding of the molecular architecture of the retrograde IFT trains is still lacking (Assante et al, 2014; Piperno et al, 1998; Mukhopadhyay et al, 2010; reviewed in Taschner et al, 2012).

Literature References
PubMed ID Title Journal Year
15269286 A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar transport

Hou, Y, Pazour, GJ, Witman, GB

Mol. Biol. Cell 2004
21427764 Ciliogenesis: building the cell's antenna

Ishikawa, H, Marshall, WF

Nat. Rev. Mol. Cell Biol. 2011
19450523 SnapShot: Intraflagellar transport

Cole, DG, Snell, WJ

Cell 2009
9585416 A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT)

Pazour, GJ, Wilkerson, CG, Witman, GB

J. Cell Biol. 1998
11285270 Protein particles in Chlamydomonas flagella undergo a transport cycle consisting of four phases

Iomini, C, Babaev-Khaimov, V, Sassaroli, M, Piperno, G

J. Cell Biol. 2001
9852153 Distinct mutants of retrograde intraflagellar transport (IFT) share similar morphological and molecular defects

Piperno, G, Siuda, E, Henderson, S, Segil, M, Vaananen, H, Sassaroli, M

J. Cell Biol. 1998
19720863 Retrograde intraflagellar transport mutants identify complex A proteins with multiple genetic interactions in Chlamydomonas reinhardtii

Iomini, C, Li, L, Esparza, JM, Dutcher, SK

Genetics 2009
10069812 Cytoplasmic dynein heavy chain 1b is required for flagellar assembly in Chlamydomonas

Porter, ME, Bower, R, Knott, JA, Byrd, P, Dentler, W

Mol. Biol. Cell 1999
20889716 TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

Mukhopadhyay, S, Wen, X, Chih, B, Nelson, CD, Lane, WS, Scales, SJ, Jackson, PK

Genes Dev. 2010
22992454 Intraflagellar transport proteins cycle between the flagellum and its base

Buisson, J, Chenouard, N, Lagache, T, Blisnick, T, Olivo-Marin, JC, Bastin, P

J. Cell. Sci. 2013
25205765 Subunit composition of the human cytoplasmic dynein-2 complex

Asante, D, Stevenson, NL, Stephens, DJ

J. Cell. Sci. 2014
22118932 Architecture and function of IFT complex proteins in ciliogenesis

Taschner, M, Bhogaraju, S, Lorentzen, E

Differentiation 2012
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