KIF17 enters the cilium

Stable Identifier
R-HSA-5624948
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
KIF7 dimer:TNPO1 translocates to the cilium
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Ciliary localization of the alternative kinesin-2 motor KIF17 depends on TNPO1 and the RAN:GDP/RAN:GTP gradient. Once in the cilium, the TNPO1:KIF17 complex is likely dissociated by RAN:GTP binding and subsequent GTP hydrolysis, freeing KIF17 to play its role in anterograde IFT transport (Dishinger et al, 2010).

Literature References
PubMed ID Title Journal Year
20526328 Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP

Dishinger, JF, Kee, HL, Jenkins, PM, Fan, S, Hurd, TW, Hammond, JW, Truong, YN, Margolis, B, Martens, JR, Verhey, KJ

Nat. Cell Biol. 2010
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Orthologous Events
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