Reactome | KIF17 enters the cilium

KIF17 enters the cilium

Stable Identifier

R-HSA-5624948

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cilium

Synonyms

KIF7 dimer:TNPO1 translocates to the cilium

ReviewStatus

5/5

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Ciliary localization of the alternative kinesin-2 motor KIF17 depends on TNPO1 and the RAN:GDP/RAN:GTP gradient. Once in the cilium, the TNPO1:KIF17 complex is likely dissociated by RAN:GTP binding and subsequent GTP hydrolysis, freeing KIF17 to play its role in anterograde IFT transport (Dishinger et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
20526328	Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP Hurd, TW, Kee, HL, Martens, JR, Truong, YN, Hammond, JW, Jenkins, PM, Verhey, KJ, Dishinger, JF, Fan, S, Margolis, B	Nat. Cell Biol.	2010