Reactome | SAMHD1 [nucleoplasm]

SAMHD1 [nucleoplasm]

Stable Identifier

R-HSA-5624198

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, SAMH1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P58753%20TIRAP

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External Reference Information

External Reference

UniProt:Q9Y3Z3 SAMHD1

Gene Names

SAMHD1, MOP5

Chain

chain:1-626

Reference Genes

BioGPS Gene:25939 SAMHD1

COSMIC (genes):SAMHD1 SAMHD1

CTD Gene:25939 SAMHD1

dbSNP Gene:25939 SAMHD1

ENSEMBL:ENSG00000101347 SAMHD1

ENSEMBL_homo_sapiens_GENE:ENSG00000101347.11 SAMHD1

HGNC:15925 SAMHD1

KEGG Gene (Homo sapiens):25939 SAMHD1

Monarch:25939 SAMHD1

NCBI Gene:25939 SAMHD1

OMIM:606754 SAMHD1

UCSC:Q9Y3Z3 SAMHD1

Reference Transcript

Other Identifiers

11739148_a_at

11739149_a_at

11748841_a_at

11749510_a_at

1559883_PM_s_at

1559883_s_at

16919022

204502_PM_at

204502_at

234987_PM_at

234987_at

235529_PM_x_at

235529_x_at

235964_PM_x_at

235964_x_at

25939

34714_at

3904692

3904693

3904694

3904695

3904704

3904705

3904706

3904707

3904709

3904710

3904711

3904714

3904717

3904718

3904720

3904722

3904723

3904725

3904728

3904729

3904730

3904731

3904732

44583_at

61839_at

8066117

A_24_P267592

A_33_P3406281

GE58609

GO:0000166

GO:0000724

GO:0002376

GO:0003676

GO:0003677

GO:0003697

GO:0003723

GO:0003824

GO:0004540

GO:0005515

GO:0005525

GO:0005634

GO:0005654

GO:0005694

GO:0005886

GO:0006203

GO:0006260

GO:0006281

GO:0006310

GO:0006955

GO:0006974

GO:0008152

GO:0008270

GO:0008832

GO:0009264

GO:0016446

GO:0016787

GO:0016793

GO:0023052

GO:0032567

GO:0035861

GO:0042802

GO:0043226

GO:0045087

GO:0045088

GO:0046061

GO:0046872

GO:0048856

GO:0051289

GO:0051607

GO:0055086

GO:0060339

GO:0065003

GO:0097197

GO:0098542

GO:0106375

GO:0110025

GO:0140098

GO:1901135

HMNXSV003044373

Hs.293684.1.A1_3p_at

Hs.293684.2.S1_3p_a_at

ILMN_1721026

PH_hs_0029905

TC20000821.hg

g7661593_3p_at

Participates

as an output of

Expression of IFN-induced genes (Homo sapiens)

as a component of

SAMHD1:Zn2+ tetramer [nucleoplasm] (Homo sapiens)

Inferred To

samhd1 [nucleoplasm] (Xenopus tropicalis)

fal [nucleoplasm] (Drosophila melanogaster)

SAMHD1 [nucleoplasm] (Bos taurus)

SAMHD1 [nucleoplasm] (Caenorhabditis elegans)

SAMHD1 [nucleoplasm] (Canis familiaris)

SAMHD1 [nucleoplasm] (Danio rerio)

SAMHD1 [nucleoplasm] (Dictyostelium discoideum)

SAMHD1 [nucleoplasm] (Gallus gallus)

SAMHD1 [nucleoplasm] (Mus musculus)

SAMHD1 [nucleoplasm] (Plasmodium falciparum)

SAMHD1 [nucleoplasm] (Sus scrofa)

Samhd1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_056289.2, XP_005260441.1

OpenTargets

ENSG00000101347

GeneCards

Q9Y3Z3

HPA

ENSG00000101347-SAMHD1

Ensembl

ENST00000682773, ENSP00000507178, ENST00000646869, ENSP00000262878, ENST00000683766, ENSP00000495432, ENST00000646673, ENSG00000101347, ENST00000646066, ENSP00000493810, ENSP00000493536, ENST00000644250, ENSP00000495667, ENST00000262878, ENSP00000506877

PRO

Q9Y3Z3

Pharos - Targets

Q9Y3Z3

Orphanet

18469

PDB

6DW7, 4TO1, 4RXR, 6TX0, 5AO3, 4TNZ, 7LU5, 4ZWG, 5AO1, 4TNY, 6U6Z, 8D94, 4RXQ, 6YOM, 4QFZ, 4ZWE, 6CM2, 6DW3, 7LTT, 4RXO, 4QFY, 4QG1, 7S2Y, 6U6X, 6DWK, 4BZC, 8GB1, 4BZB, 4TO5, 6TXC, 8D9J, 3U1N, 6DWD, 4TO3, 6TXA, 7UJN, 4TO2, 4Q7H, 5AO4, 4QG4, 4QG2, 6DW5, 2E8O, 5AO2, 4TO0, 4QFX, 4RXP, 4QG0, 5AO0, 6DW4, 6U6Y, 4TNX, 7A5Y, 4TNR, 6TXF, 4MZ7, 6TXE, 4TO6, 6DWJ, 4TNQ, 8GB2, 4TNP, 6XU1, 4CC9, 4TO4, 4RXS

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y3Z3 SAMHD1	1	SAMHD1 [nucleoplasm] (R-HSA-5624198)	0.76	7
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	11
UniProt:Q9Y4B6 VPRBP	1	VPRBP [cytosol] (R-HSA-975984)	0.544	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.499	2
UniProt:Q08380 LGALS3BP	2	LGALS3BP [extracellular region] (R-HSA-8848882) LGALS3BP [platelet dense granule lumen] (R-HSA-8848916)	0.499	2
IntAct:EBI-15928529 VPX			0.462	2
UniProt:O75923 DYSF	1	DYSF [cytoplasmic vesicle membrane] (R-HSA-5263626)	0.454	2

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