ARL6:GTP and the BBSome target cargo to the primary cilium

Stable Identifier
R-HSA-5624127
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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ARL6:GTP and the BBSome complex are required for the ciliary accumulation of proteins such as SSTR3, MHRC1 and SMO (Zhang et al, 2011; Jin et al, 2010; Seo et al, 2011; reviewed in Nachury et al, 2010; Sung and Leroux, 2013). BBSome localization to the primary cilium is negatively regulated by LZTFL1, and ciliary accumulation of some BBSome cargo is increased by LZTFL1 depletion (Seo et al, 2011).

Literature References
PubMed ID Title Journal Year
22139371 Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes

Zhang, Q, Nishimura, D, Seo, S, Vogel, T, Morgan, DA, Searby, C, Bugge, K, Stone, EM, Rahmouni, K, Sheffield, VC

Proc. Natl. Acad. Sci. U.S.A. 2011
20603001 The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia

Jin, H, White, SR, Shida, T, Schulz, S, Aguiar, M, Gygi, SP, Bazan, JF, Nachury, MV

Cell 2010
22072986 A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened

Seo, S, Zhang, Q, Bugge, K, Breslow, DK, Searby, CC, Nachury, MV, Sheffield, VC

PLoS Genet. 2011
24296415 The roles of evolutionarily conserved functional modules in cilia-related trafficking

Sung, CH, Leroux, MR

Nat. Cell Biol. 2013
19575670 Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier?

Nachury, MV, Seeley, ES, Jin, H

Annu. Rev. Cell Dev. Biol. 2010
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