Reactome | CNGB1 [Golgi membrane]

CNGB1 [Golgi membrane]

Stable Identifier

R-HSA-5624056

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

CNCG2, CNCG3L, CNCG4, RCNC2

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - VxPx cargo-targeting to cilium (Homo sapiens)
      - ARF4:GTP binds VxPx-motifs of membrane proteins (Homo sapiens)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGB1 [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGB1 [Golgi membrane] (Homo sapiens)
      - ASAP1 dimer binds membrane proteins (Homo sapiens)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGB1 [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGB1 [Golgi membrane] (Homo sapiens)
      - ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Homo sapiens)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGB1 [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGB1 [Golgi membrane] (Homo sapiens)
      - ASAP1 stimulates GTPase activity of ARF4 (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGB1 [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGB1 [Golgi membrane] (Homo sapiens)
      - Cargo-carrying vesicles bud from the TGN (Homo sapiens)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGB1 [Golgi membrane] (Homo sapiens)
      - RAB3IP and RAB8A bind to the ciliary targeting complex (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGB1 [Golgi membrane] (Homo sapiens)
        
        RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGB1 [Golgi membrane] (Homo sapiens)
      - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
        
        RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGB1 [Golgi membrane] (Homo sapiens)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGB1 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14028 CNGB1

Gene Names

CNGB1, CNCG2, CNCG3L, CNCG4, RCNC2

Chain

chain:1-1251

Reference Genes

BioGPS Gene:1258 CNGB1

COSMIC (genes):CNGB1 CNGB1

CTD Gene:1258 CNGB1

dbSNP Gene:1258 CNGB1

ENSEMBL:ENSG00000070729 CNGB1

HGNC:2151 CNGB1

KEGG:hsa:1258 CNGB1

Monarch:1258 CNGB1

NCBI Gene:1258 CNGB1

OMIM:600724 CNGB1

UCSC:Q14028 CNGB1

Reference Transcript

Participates

as a component of

CNG tetramer [Golgi membrane] (Homo sapiens)

Other forms of this molecule

CNGB1 [ciliary membrane]

CNGB1 [Golgi-associated vesicle membrane]

CNGB1 [plasma membrane]

Inferred To

CNGB1 [Golgi membrane] (Bos taurus)

CNGB1 [Golgi membrane] (Canis familiaris)

CNGB1 [Golgi membrane] (Gallus gallus)

CNGB1 [Golgi membrane] (Sus scrofa)

Cngb1 [Golgi membrane] (Mus musculus)

Cngb1 [Golgi membrane] (Rattus norvegicus)

CngB [Golgi membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001129111.1, NP_001288.3, NP_001273059.1

Guide to Pharmacology - Targets

398

ENSEMBL

ENSG00000070729, ENSP00000311670, ENSP00000251102, ENSP00000454633, ENST00000251102, ENST00000311183, ENST00000564448

OpenTargets

ENSG00000070729

GeneCards

CNGB1

HPA

ENSG00000070729-CNGB1

PRO

Q14028

Pharos - Targets

Q14028

GlyGen

Q14028

Orphanet

CNGB1

HMDB Protein

HMDBP10837

PDB

8DGK, 8DGH, 7RHH, 7RHK, 7RH9, 7RHI, 7RHG, 7RHL, 7RHJ

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