Reactome | CNGA4 [Golgi membrane]

CNGA4 [Golgi membrane]

Stable Identifier

R-HSA-5624055

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

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Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - VxPx cargo-targeting to cilium (Homo sapiens)
      - ARF4:GTP binds VxPx-motifs of membrane proteins (Homo sapiens)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGA4 [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGA4 [Golgi membrane] (Homo sapiens)
      - ASAP1 dimer binds membrane proteins (Homo sapiens)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGA4 [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGA4 [Golgi membrane] (Homo sapiens)
      - ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Homo sapiens)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGA4 [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGA4 [Golgi membrane] (Homo sapiens)
      - ASAP1 stimulates GTPase activity of ARF4 (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGA4 [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGA4 [Golgi membrane] (Homo sapiens)
      - Cargo-carrying vesicles bud from the TGN (Homo sapiens)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGA4 [Golgi membrane] (Homo sapiens)
      - RAB3IP and RAB8A bind to the ciliary targeting complex (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGA4 [Golgi membrane] (Homo sapiens)
        
        RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGA4 [Golgi membrane] (Homo sapiens)
      - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
        
        RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGA4 [Golgi membrane] (Homo sapiens)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        VxPx-containing ciliary membrane proteins [Golgi membrane] (Homo sapiens)
        
        CNG tetramer [Golgi membrane] (Homo sapiens)
        
        CNGA4 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IV77 CNGA4

Gene Names

CNGA4

Chain

chain:1-575

Reference Genes

BioGPS Gene:1262 CNGA4

COSMIC (genes):CNGA4 CNGA4

CTD Gene:1262 CNGA4

dbSNP Gene:1262 CNGA4

ENSEMBL:ENSG00000132259 CNGA4

ENSEMBL_homo_sapiens_GENE:ENSG00000132259.13 CNGA4

HGNC:2152 CNGA4

KEGG Gene (Homo sapiens):1262 CNGA4

Monarch:1262 CNGA4

NCBI Gene:1262 CNGA4

OMIM:609472 CNGA4

UCSC:Q8IV77 CNGA4

Reference Transcript

RefSeq:NM_001037329.3 CNGA4

Other Identifiers

11751735_a_at

11755926_a_at

1262

1562273_PM_at

1562273_at

16721341

3318621

3318622

3318624

3318625

3318627

3318628

3318630

7938082

A_23_P2006

GO:0000166

GO:0005215

GO:0005216

GO:0005222

GO:0005223

GO:0005886

GO:0005929

GO:0006811

GO:0007608

GO:0016020

GO:0017071

GO:0030552

GO:0030553

GO:0030660

GO:0031410

GO:0034220

GO:0043226

GO:0044877

GO:0050877

GO:0050896

GO:0055085

GO:0060170

GO:0098655

HMNXSV003053738

Hs2.434308.1.S1_3p_at

ILMN_2087931

PH_hs_0020316

TC11000128.hg

Participates

as a component of

CNG tetramer [Golgi membrane] (Homo sapiens)

Other forms of this molecule

CNGA4 [plasma membrane]

CNGA4 [ciliary membrane]

CNGA4 [Golgi-associated vesicle membrane]

Inferred To

cng-2 [Golgi membrane] (Caenorhabditis elegans)

Homologues of CNGA4 [Golgi membrane] (Caenorhabditis elegans)

Homologues of CNGA4 [Golgi membrane] (Drosophila melanogaster)

cng-3 [Golgi membrane] (Caenorhabditis elegans)

cng-1 [Golgi membrane] (Caenorhabditis elegans)

Dmel\CG42260 [Golgi membrane] (Drosophila melanogaster)

CNGA4 [Golgi membrane] (Bos taurus)

CNGA4 [Golgi membrane] (Caenorhabditis elegans)

CNGA4 [Golgi membrane] (Canis familiaris)

CNGA4 [Golgi membrane] (Drosophila melanogaster)

CNGA4 [Golgi membrane] (Mus musculus)

CNGA4 [Golgi membrane] (Rattus norvegicus)

CNGA4 [Golgi membrane] (Sus scrofa)

che-6 [Golgi membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001032406.1

Guide to Pharmacology - Targets

397

OpenTargets

ENSG00000132259

HPA

ENSG00000132259-CNGA4

GeneCards

Q8IV77

Ensembl

ENSP00000369268, ENSG00000132259, ENST00000379936

PRO

Q8IV77

Pharos - Targets

Q8IV77

HMDB Protein

HMDBP07616

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