Reactome | PDPK1 phosphorylates PKN1,2,3

PDPK1 phosphorylates PKN1,2,3

Stable Identifier

R-HSA-5623667

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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PDPK1 (PDK1) phosphorylates PKN1, PKN2 and likely PKN3 on a highly conserved threonine residue (T774 of PKN1, T816 of PKN2, T718 of PKN3) in the kinase activation loop. Although phosphorylation of PKN1, PKN2 and PKN3 at other sites may be needed for them to achieve the full catalytic activity, PDPK1-mediated phosphorylation of the activation loop is a necessary step in PKN1, PKN2 and likely PKN3 activation. This reaction happens while the PKN protein is complexed with a RHO GTPase and PIP3-bound PDPK1 (Flynn et al. 2000, Torbett et al. 2003, Dettori et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
12783890	Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1 Casamassima, A, Parker, PJ, Torbett, NE	J. Biol. Chem.	2003
10753910	Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase Flynn, P, Casamassima, A, Parker, PJ, Mellor, H	J. Biol. Chem.	2000
19723632	Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) Engel, M, Dettori, R, Sonzogni, S, Piiper, A, Frödin, M, Neimanis, S, Zeuzem, S, Morrice, NA, Meyer, L, Lopez-Garcia, LA, Biondi, RM	J. Biol. Chem.	2009