RDH13 reduces atRAL to atROL

Stable Identifier
R-HSA-5623643
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane, mitochondrial intermembrane space
ReviewStatus
5/5
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RDH13 reduces atRAL to atROL
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Multiple reductases may contribute to the reduction of all-trans-retinal (atRAL) to all-trans-retinol (atROL). Human retinol dehydrogenase 13 (RDH13) is located on the outer surface of the mitochondrial inner membrane where it is thought to protect mitochondria against oxidative stress associated with the highly reactive retinaldehyde (Belyaeva et al. 2008).

Literature References
PubMed ID Title Journal Year
18039331 Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity

Belyaeva, OV, Korkina, OV, Stetsenko, AV, Kedishvili, NY

FEBS J. 2008
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as an event of
Catalyst Activity

NADP-retinol dehydrogenase activity of RDH13 [mitochondrial inner membrane]

Physical Entity
RDH13 [mitochondrial inner membrane] (Homo sapiens)
Activity
NADP-retinol dehydrogenase activity (GO:0052650)
Orthologous Events
RDH13 reduces atRAL to atROL (Bos taurus)
RDH13 reduces atRAL to atROL (Caenorhabditis elegans)
RDH13 reduces atRAL to atROL (Canis familiaris)
RDH13 reduces atRAL to atROL (Dictyostelium discoideum)
RDH13 reduces atRAL to atROL (Drosophila melanogaster)
RDH13 reduces atRAL to atROL (Mus musculus)
RDH13 reduces atRAL to atROL (Plasmodium falciparum)
RDH13 reduces atRAL to atROL (Rattus norvegicus)
RDH13 reduces atRAL to atROL (Sus scrofa)
Cross References
Rhea
Authored
Jassal, B  (2014-09-18)
Reviewed
Duester, G  (2014-07-28)
Napoli, JL  (2014-09-01)
Created
Jassal, B  (2014-09-18)
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