RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3

Stable Identifier
R-HSA-5623632
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Binding of PKN1, PKN2 or PKN3 to any of the RHO GTP-ases RHOA, RHOB, RHOC or RAC1 enables PKN1, PKN2 and PKN3 to interact with PIP3-activated kinase PDPK1, through the formation of ternary complexes (Flynn et al. 2000, Torbett et al. 2003).

Literature References
PubMed ID Title Journal Year
10753910 Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase

Flynn, P, Mellor, H, Casamassima, A, Parker, PJ

J. Biol. Chem. 2000
12783890 Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1

Torbett, NE, Casamassima, A, Parker, PJ

J. Biol. Chem. 2003
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