Reactome | RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3

RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3

Stable Identifier

R-HSA-5623632

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

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RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3

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Binding of PKN1, PKN2 or PKN3 to any of the RHO GTP-ases RHOA, RHOB, RHOC or RAC1 enables PKN1, PKN2 and PKN3 to interact with PIP3-activated kinase PDPK1, through the formation of ternary complexes (Flynn et al. 2000, Torbett et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
10753910	Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase Flynn, P, Mellor, H, Casamassima, A, Parker, PJ	J. Biol. Chem.	2000
12783890	Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1 Torbett, NE, Casamassima, A, Parker, PJ	J. Biol. Chem.	2003