Reactome | RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3

RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3

Stable Identifier

R-HSA-5623632

Type

Reaction

Species

Homo sapiens

Compartment

plasma membrane

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RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3

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Binding of PKN1, PKN2 or PKN3 to any of the RHO GTP-ases RHOA, RHOB, RHOC or RAC1 enables PKN1, PKN2 and PKN3 to interact with PIP3-activated kinase PDPK1, through the formation of ternary complexes (Flynn et al. 2000, Torbett et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12783890	Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1 Casamassima, A, Parker, PJ, Torbett, NE	J. Biol. Chem.	2003
10753910	Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase Flynn, P, Casamassima, A, Parker, PJ, Mellor, H	J. Biol. Chem.	2000