VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane

Stable Identifier
R-HSA-5623527
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
VxPx-containing ciliary membrane proteins translocate to the ciliary membrane
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Exocyst-mediated fusion of the Golgi-derived vesicle delivers the VxPx-containing membrane proteins to the ciliary membrane, although the precise mechanisms remain to be worked out (Mazelova et al, 2009; Wang et al, 2012; reviewed in Sung and Leroux, 2013). Vesicles carrying membrane proteins destined for the cilum may fuse at the periciliary membrane at the base of the cilium and deliver cargo to the IFT system. Ciliary membrane proteins may also diffuse laterally into the periciliary membrane after fusion of vesicles with the plasma membrane (reviewed in Hsiao et al, 2012; Sung and Leroux, 2013). Although not depicted in this reaction, there is evidence that some of the protein-protein interactions of the ciliary-targeting complex may persist into the periciliary or ciliary membrane region (Wang et al, 2012).

Literature References
PubMed ID Title Journal Year
24296415 The roles of evolutionarily conserved functional modules in cilia-related trafficking

Sung, CH, Leroux, MR

Nat. Cell Biol. 2013
23351793 Trafficking in and to the primary cilium

Hsiao, YC, Tuz, K, Ferland, RJ

Cilia 2012
19454479 Syntaxin 3 and SNAP-25 pairing, regulated by omega-3 docosahexaenoic acid, controls the delivery of rhodopsin for the biogenesis of cilia-derived sensory organelles, the rod outer segments

Mazelova, J, Ransom, N, Astuto-Gribble, L, Wilson, MC, Deretic, D

J. Cell. Sci. 2009
22983554 The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting

Wang, J, Morita, Y, Mazelova, J, Deretic, D

EMBO J. 2012
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