Reactome | VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane

VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane

Stable Identifier

R-HSA-5623527

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

ciliary membrane

Synonyms

VxPx-containing ciliary membrane proteins translocate to the ciliary membrane

ReviewStatus

5/5

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VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane

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Exocyst-mediated fusion of the Golgi-derived vesicle delivers the VxPx-containing membrane proteins to the ciliary membrane, although the precise mechanisms remain to be worked out (Mazelova et al, 2009; Wang et al, 2012; reviewed in Sung and Leroux, 2013). Vesicles carrying membrane proteins destined for the cilium may fuse at the periciliary membrane at the base of the cilium and deliver cargo to the IFT system. Ciliary membrane proteins may also diffuse laterally into the periciliary membrane after fusion of vesicles with the plasma membrane (reviewed in Hsiao et al, 2012; Sung and Leroux, 2013). Although not depicted in this reaction, there is evidence that some of the protein-protein interactions of the ciliary-targeting complex may persist into the periciliary or ciliary membrane region (Wang et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
23351793	Trafficking in and to the primary cilium Hsiao, YC, Tuz, K, Ferland, RJ	Cilia	2012
24296415	The roles of evolutionarily conserved functional modules in cilia-related trafficking Sung, CH, Leroux, MR	Nat. Cell Biol.	2013
19454479	Syntaxin 3 and SNAP-25 pairing, regulated by omega-3 docosahexaenoic acid, controls the delivery of rhodopsin for the biogenesis of cilia-derived sensory organelles, the rod outer segments Mazelova, J, Ransom, N, Astuto-Gribble, L, Wilson, MC, Deretic, D	J. Cell. Sci.	2009
22983554	The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting Wang, J, Morita, Y, Mazelova, J, Deretic, D	EMBO J.	2012