Reactome | Cargo-carrying vesicles bud from the TGN

Cargo-carrying vesicles bud from the TGN

Stable Identifier

R-HSA-5623525

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

Golgi-associated vesicle membrane

ReviewStatus

5/5

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Cargo-carrying vesicles bud from the TGN

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Membrane budding at the trans-Golgi network is promoted at least in part by the BAR domain of ASAP1, which is involved in sensing and inducing membrane curvature as well as providing the recognition site for small GTPases (Nie et al, 2006; Jian et al, 2009; Inoue et al, 2008; reviewed in Masuda et al, 2010). Oligomerization between ASAP1 and RAB11FIP3 may contribute to coat formation on vesicles budding from the TGN and destined for the plasma or ciliary membrane (Inoue et al, 2008; Mazelova et al, 2009; reviewed in Deretic, 2013).

Literature References

PubMed ID	Title	Journal	Year
18685082	Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome Inoue, H, Ha, VL, Prekeris, R, Randazzo, PA	Mol. Biol. Cell	2008
19153612	Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4 Mazelova, J, Astuto-Gribble, L, Inoue, H, Tam, BM, Schonteich, E, Prekeris, R, Moritz, OL, Randazzo, PA, Deretic, D	EMBO J.	2009
20083215	Structural characteristics of BAR domain superfamily to sculpt the membrane Masuda, M, Mochizuki, N	Semin. Cell Dev. Biol.	2010
16431365	A BAR domain in the N terminus of the Arf GAP ASAP1 affects membrane structure and trafficking of epidermal growth factor receptor Nie, Z, Hirsch, DS, Luo, R, Jian, X, Stauffer, S, Cremesti, A, Andrade, J, Lebowitz, J, Marino, M, Ahvazi, B, Hinshaw, JE, Randazzo, PA	Curr. Biol.	2006
19017632	Autoinhibition of Arf GTPase-activating protein activity by the BAR domain in ASAP1 Jian, X, Brown, P, Schuck, P, Gruschus, JM, Balbo, A, Hinshaw, JE, Randazzo, PA	J. Biol. Chem.	2009
23567335	Crosstalk of Arf and Rab GTPases en route to cilia Deretic, D	Small GTPases	2013