Reactome | The exocyst complex binds to RAB3IP in the ciliary targeting complex

The exocyst complex binds to RAB3IP in the ciliary targeting complex

Stable Identifier

R-HSA-5623524

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi-associated vesicle membrane

ReviewStatus

5/5

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The exocyst complex binds to RAB3IP in the ciliary targeting complex

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RAB3IP interacts directly with the EXOC6/SEC15 component of the exocyst, recruiting this membrane-targeting complex to the Golgi-derived vesicles (Feng et al, 2012; reviewed in Deretic, 2013). The exocyst is an octameric complex with roles in tethering and fusion of secretory vesicles with target membranes. A number of the exocyst components have been shown to be localized to the ciliary base and/or to be required for ciliogenesis. Consistent with this, IQCB1/NPHP5, a component of the basal body, has been shown to interact with members of the exocyst complex (Wu et al, 2005; Rogers et al, 2004; Zuo et al, 2009; Feng et al, 2012; Sang et al, 2011; reviewed in Das and Guo, 2011; Heider and Munson, 2012).

Literature References

PubMed ID	Title	Journal	Year
22420621	Exorcising the exocyst complex Heider, MR, Munson, M	Traffic	2012
19297529	The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro Zuo, X, Guo, W, Lipschutz, JH	Mol. Biol. Cell	2009
21565611	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways Sang, L, Miller, JJ, Corbit, KC, Giles, RH, Brauer, MJ, Otto, EA, Baye, LM, Wen, X, Scales, SJ, Kwong, M, Huntzicker, EG, Sfakianos, MK, Sandoval, W, Bazan, JF, Kulkarni, P, Garcia-Gonzalo, FR, Seol, AD, O'Toole, JF, Held, S, Reutter, HM, Lane, WS, Rafiq, MA, Noor, A, Ansar, M, Devi, AR, Sheffield, VC, Slusarski, DC, Vincent, JB, Doherty, DA, Hildebrandt, F, Reiter, JF, Jackson, PK	Cell	2011
21550243	Rabs and the exocyst in ciliogenesis, tubulogenesis and beyond Das, A, Guo, W	Trends Cell Biol.	2011
22433857	A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis Feng, S, Knödler, A, Ren, J, Zhang, J, Zhang, X, Hong, Y, Huang, S, Peränen, J, Guo, W	J. Biol. Chem.	2012
15158452	The exocyst localizes to the primary cilium in MDCK cells Rogers, KK, Wilson, PD, Snyder, RW, Zhang, X, Guo, W, Burrow, CR, Lipschutz, JH	Biochem. Biophys. Res. Commun.	2004
16155582	Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo Wu, S, Mehta, SQ, Pichaud, F, Bellen, HJ, Quiocho, FA	Nat. Struct. Mol. Biol.	2005
23567335	Crosstalk of Arf and Rab GTPases en route to cilia Deretic, D	Small GTPases	2013