The exocyst complex binds to RAB3IP in the ciliary targeting complex

Stable Identifier
R-HSA-5623524
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RAB3IP interacts directly with the EXOC6/SEC15 component of the exocyst, recruiting this membrane-targeting complex to the Golgi-derived vesicles (Feng et al, 2012; reviewed in Deretic, 2013). The exocyst is an octameric complex with roles in tethering and fusion of secretory vesicles with target membranes. A number of the exocyst components have been shown to be localized to the ciliary base and/or to be required for ciliogenesis. Consistent with this, IQCB1/NPHP5, a component of the basal body, has been shown to interact with members of the exocyst complex (Wu et al, 2005; Rogers et al, 2004; Zuo et al, 2009; Feng et al, 2012; Sang et al, 2011; reviewed in Das and Guo, 2011; Heider and Munson, 2012).

Literature References
PubMed ID Title Journal Year
19297529 The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro

Zuo, X, Guo, W, Lipschutz, JH

Mol. Biol. Cell 2009
22420621 Exorcising the exocyst complex

Heider, MR, Munson, M

Traffic 2012
21565611 Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways

Sang, L, Miller, JJ, Corbit, KC, Giles, RH, Brauer, MJ, Otto, EA, Baye, LM, Wen, X, Scales, SJ, Kwong, M, Huntzicker, EG, Sfakianos, MK, Sandoval, W, Bazan, JF, Kulkarni, P, Garcia-Gonzalo, FR, Seol, AD, O'Toole, JF, Held, S, Reutter, HM, Lane, WS, Rafiq, MA, Noor, A, Ansar, M, Devi, AR, Sheffield, VC, Slusarski, DC, Vincent, JB, Doherty, DA, Hildebrandt, F, Reiter, JF, Jackson, PK

Cell 2011
21550243 Rabs and the exocyst in ciliogenesis, tubulogenesis and beyond

Das, A, Guo, W

Trends Cell Biol. 2011
22433857 A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis

Feng, S, Knödler, A, Ren, J, Zhang, J, Zhang, X, Hong, Y, Huang, S, Peränen, J, Guo, W

J. Biol. Chem. 2012
15158452 The exocyst localizes to the primary cilium in MDCK cells

Rogers, KK, Wilson, PD, Snyder, RW, Zhang, X, Guo, W, Burrow, CR, Lipschutz, JH

Biochem. Biophys. Res. Commun. 2004
16155582 Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo

Wu, S, Mehta, SQ, Pichaud, F, Bellen, HJ, Quiocho, FA

Nat. Struct. Mol. Biol. 2005
23567335 Crosstalk of Arf and Rab GTPases en route to cilia

Deretic, D

Small GTPases 2013
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