Reactome | GBF1 stimulates nucleotide exchange on ARF4

GBF1 stimulates nucleotide exchange on ARF4

Stable Identifier

R-HSA-5623508

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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GBF1 stimulates nucleotide exchange on ARF4

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GBF1 promotes guanine nucleotide exchange on ARF4 at the Golgi membrane, activating the small GTPase and promoting its association with the Golgi membrane (Szul et al, 2007; reviewed in Deretic, 2013). Activated ARF4 at the trans-Golgi network may represent the initial sorting point for membrane proteins destined for the cilium (reviewed in Li et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
22389062	The emerging role of Arf/Arl small GTPases in cilia and ciliopathies Ling, K, Hu, J, Li, Y	J. Cell. Biochem.	2012
23567335	Crosstalk of Arf and Rab GTPases en route to cilia Deretic, D	Small GTPases	2013
17956946	Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking Grabski, R, Shestopal, S, Morohashi, Y, Lyons, S, Sztul, E, Szul, T, Lowe, M	J. Cell. Sci.	2007