GBF1 stimulates nucleotide exchange on ARF4

Stable Identifier
R-HSA-5623508
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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GBF1 promotes guanine nucleotide exchange on ARF4 at the Golgi membrane, activating the small GTPase and promoting its association with the Golgi membrane (Szul et al, 2007; reviewed in Deretic, 2013). Activated ARF4 at the trans-Golgi network may represent the initial sorting point for membrane proteins destined for the cilium (reviewed in Li et al, 2012).

Literature References
PubMed ID Title Journal Year
23567335 Crosstalk of Arf and Rab GTPases en route to cilia

Deretic, D

Small GTPases 2013
22389062 The emerging role of Arf/Arl small GTPases in cilia and ciliopathies

Li, Y, Ling, K, Hu, J

J. Cell. Biochem. 2012
17956946 Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking

Szul, T, Grabski, R, Lyons, S, Morohashi, Y, Shestopal, S, Lowe, M, Sztul, E

J. Cell. Sci. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ARF guanyl-nucleotide exchange factor activity of GBF1 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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