GBF1 stimulates nucleotide exchange on ARF4

Stable Identifier
Reaction [transition]
Homo sapiens
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GBF1 promotes guanine nucleotide exchange on ARF4 at the Golgi membrane, activating the small GTPase and promoting its association with the Golgi membrane (Szul et al, 2007; reviewed in Deretic, 2013). Activated ARF4 at the trans-Golgi network may represent the initial sorting point for membrane proteins destined for the cilium (reviewed in Li et al, 2012).

Literature References
PubMed ID Title Journal Year
22389062 The emerging role of Arf/Arl small GTPases in cilia and ciliopathies

Ling, K, Hu, J, Li, Y

J. Cell. Biochem. 2012
23567335 Crosstalk of Arf and Rab GTPases en route to cilia

Deretic, D

Small GTPases 2013
17956946 Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking

Grabski, R, Shestopal, S, Morohashi, Y, Lyons, S, Sztul, E, Szul, T, Lowe, M

J. Cell. Sci. 2007
Catalyst Activity

guanyl-nucleotide exchange factor activity of GBF1 [Golgi membrane]

Orthologous Events
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