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CSH1 [extracellular region]
Stable Identifier
R-HSA-5622079
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Chorionic somatomammotropin hormone 1, CSH1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Growth hormone receptor signaling (Homo sapiens)
JAK2 phosphorylation (Homo sapiens)
Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
Prolactin receptor signaling (Homo sapiens)
JAK2 phosphorylation (Homo sapiens)
Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR activation (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR binds SCF beta-TrCP complex (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR binds SHP2 (PTPN11) (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR binds STAT5 (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR is phosphorylated at Ser-349 (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR-bound STAT5 is phosphorylated (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-STAT5 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
Prolactin receptor is internalized (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Homo sapiens)
2xp-S349-PRLR:2xJAK2 [endosome lumen] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
SH2B binds JAK2 (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
SHP2 is phosphorylated (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
Tyrosine phosphorylation of PRLR (Homo sapiens)
PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
Prolactin receptor ligands [extracellular region] (Homo sapiens)
Placental lactogen [extracellular region] (Homo sapiens)
CSH1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P0DML2 CSH1
Gene Names
CSH1
Chain
signal peptide:1-26, chain:27-217
Reference Genes
BioGPS Gene:1442 CSH1
COSMIC (genes):CSH1 CSH1
CTD Gene:1442 CSH1
dbSNP Gene:1442 CSH1
ENSEMBL:ENSG00000136488 CSH1
HGNC:2440 CSH1
KEGG:hsa:1442 CSH1
Monarch:1442 CSH1
NCBI Gene:1442 CSH1
OMIM:150200 CSH1
UCSC:P0DML2 CSH1
Reference Transcript
RefSeq:NM_001317.5 CSH1
Other Identifiers
11734709_x_at
11740165_x_at
11742406_x_at
11742653_x_at
11742994_x_at
11745920_x_at
11756755_x_at
1442
1444
16847686
202493_3p_x_at
202493_PM_x_at
202493_x_at
203807_3p_x_at
203807_PM_x_at
203807_x_at
205958_3p_x_at
205958_PM_x_at
205958_x_at
206475_3p_x_at
206475_PM_x_at
206475_x_at
207285_3p_x_at
207285_PM_x_at
207285_x_at
207770_PM_x_at
208293_3p_x_at
208293_PM_x_at
208293_x_at
208294_3p_x_at
208294_PM_x_at
208294_x_at
208295_3p_x_at
208295_x_at
208341_3p_x_at
208341_PM_x_at
208341_x_at
208342_3p_x_at
208342_PM_x_at
208342_x_at
208356_3p_x_at
208356_PM_x_at
208356_x_at
208357_3p_x_at
208357_PM_x_at
208357_x_at
211739_3p_x_at
211739_PM_x_at
211739_x_at
31493_s_at
36784_at
3766455
3766456
3766459
3766460
3766461
3766462
3766463
3766464
3766465
3766466
3766469
3766478
3766479
3766481
3766482
3766483
3766484
3766485
3766486
3766487
3766488
3766489
3766490
3766491
3766492
3766493
3766494
3766495
3766496
3766498
3766502
3766505
3766506
3766507
3766509
3766514
3766526
3766528
8017488
A_23_P207170
A_23_P207174
A_23_P381347
A_23_P381351
A_24_P211044
GE57462
GE57488
GO:0005131
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005783
GO:0007165
GO:0008083
GO:0031667
GO:0031904
GO:0031982
GO:0042531
GO:0043226
GO:0045927
GO:0046427
GO:0046872
GO:0048018
GO:0048513
GO:0048856
GO:0060396
GO:0098772
HMNXSV003001285
ILMN_1680436
ILMN_1691937
ILMN_1693617
ILMN_2363475
J03071_cds3_f_at
PH_hs_0032756
TC17001788.hg
TC17001790.hg
g12408683_3p_s_at
g12408683_3p_x_at
g12408684_3p_s_at
g12408684_3p_x_at
g12408686_3p_s_at
g12408686_3p_x_at
g12408688_3p_s_at
g12408690_3p_s_at
g12408691_3p_s_at
g12408691_3p_x_at
g12408693_3p_s_at
g12408695_3p_s_at
g12545371_3p_s_at
g12545373_3p_s_at
g12545375_3p_s_at
g12545377_3p_s_at
g12545380_3p_s_at
g13027811_3p_s_at
g13027813_3p_s_at
g13027815_3p_s_at
g13027817_3p_s_at
g13027819_3p_s_at
g13543525_3p_s_at
g13543525_3p_x_at
g2459881_3p_s_at
g9963798_3p_s_at
Participates
as a component of
Placental lactogen [extracellular region] (Homo sapiens)
Other forms of this molecule
CSH1 [endosome lumen]
Inferred To
GH1 [extracellular region]
(Bos taurus)
GH1 [extracellular region]
(Canis familiaris)
GH1 [extracellular region]
(Gallus gallus)
GH1 [extracellular region]
(Mus musculus)
GH1 [extracellular region]
(Rattus norvegicus)
GH1 [extracellular region]
(Sus scrofa)
Homologues of GH1 [extracellular region]
(Sus scrofa)
gh1 [extracellular region]
(Danio rerio)
smtlb [extracellular region]
(Danio rerio)
Homologues of CSH1 [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_001308.1
ENSEMBL
ENSP00000316416
,
ENST00000316193
OpenTargets
ENSG00000136488
HPA
ENSG00000136488-CSH1
PRO
P0DML2
Pharos - Targets
P0DML2
PDB
1Z7C
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00233 PSMD9
1
PSMD9 [cytosol]
(R-HSA-68810)
0.611
5
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