CD209 binds ManLAM

Stable Identifier
R-HSA-5621606
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
plasma membrane
Synonyms
DC-SIGN binds ManLAM
ReviewStatus
5/5
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CD209 binds ManLAM
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CD209 (DC-SIGN) interacts with pathogens through either mannose or fucose containing glycans. It interacts with mannose capped cell-wall component of Mycobacterium tuberculosis ManLAM (lipoarabinomannan). The carbohydrate recognition domain (CRD) of CD209 recognizes Man-LAM and lipomannans and the amount of Man-LAM determines the binding strength. The interaction of ManLAM and CD209 leads to the activation of serine/threonine kinase RAF1 and increases the production of the immunosuppressive cytokine interleukin 6 (IL6), IL10 and IL12 in the presence of Toll like receptor stimulation (Geijtenbeek et al. 2003, Gringhuis et al. 2007 & 2009).
Literature References
PubMed ID Title Journal Year
12515809 Mycobacteria target DC-SIGN to suppress dendritic cell function

Geijtenbeek, TB, Van Vliet, SJ, Koppel, EA, Sanchez-Hernandez, M, Vandenbroucke-Grauls, CM, Appelmelk, B, van Kooyk, Y

J. Exp. Med. 2003
Participants
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Authored
Garapati, P V  (2015-01-05)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-09-01)
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