CD209 (DC-SIGN) interacts with pathogens through either mannose or fucose containing glycans. It interacts with mannose capped cell-wall component of Mycobacterium tuberculosis ManLAM (lipoarabinomannan). The carbohydrate recognition domain (CRD) of CD209 recognizes Man-LAM and lipomannans and the amount of Man-LAM determines the binding strength. The interaction of ManLAM and CD209 leads to the activation of serine/threonine kinase RAF1 and increases the production of the immunosuppressive cytokine interleukin 6 (IL6), IL10 and IL12 in the presence of Toll like receptor stimulation (Geijtenbeek et al. 2003, Gringhuis et al. 2007 & 2009).
Van Vliet, SJ,
van Kooyk, Y