CD209 binds ICAM2

Stable Identifier
R-HSA-5621571
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
DC-SIGN binds ICAM2
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CD209 binds ICAM2
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CD209 (DC-SIGN) acts as an adhesion molecule and besides foreign antigens (Ags), it binds to a number of endogenous ligands, particularly to intracellular adhesion molecule 2 (ICAM2) on endothelial cells. This CD209-ICAM2 interaction regulates chemokine-induced transmigration of dendritic cells across both resting and activated endothelium (Geijtenbeek et al. 2000).

Literature References
PubMed ID Title Journal Year
11017109 DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking

Geijtenbeek, TB, Krooshoop, DJ, Bleijs, DA, van Vliet, SJ, van Duijnhoven, GC, Grabovsky, V, Alon, R, Figdor, CG, van Kooyk, Y

Nat. Immunol. 2000
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
CD209 binds ICAM2 (Mus musculus)
CD209 binds ICAM2 (Rattus norvegicus)
Authored
Garapati, P V  (2015-01-05)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-09-01)