CD209 binds ICAM2

Stable Identifier
R-HSA-5621571
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
DC-SIGN binds ICAM2
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CD209 binds ICAM2
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CD209 (DC-SIGN) acts as an adhesion molecule and besides foreign antigens (Ags), it binds to a number of endogenous ligands, particularly to intracellular adhesion molecule 2 (ICAM2) on endothelial cells. This CD209-ICAM2 interaction regulates chemokine-induced transmigration of dendritic cells across both resting and activated endothelium (Geijtenbeek et al. 2000).

Literature References
PubMed ID Title Journal Year
11017109 DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking

Geijtenbeek, TB, Krooshoop, DJ, Bleijs, DA, van Vliet, SJ, van Duijnhoven, GC, Grabovsky, V, Alon, R, Figdor, CG, van Kooyk, Y

Nat. Immunol. 2000
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
CD209 binds ICAM2 (Danio rerio)
CD209 binds ICAM2 (Mus musculus)
CD209 binds ICAM2 (Rattus norvegicus)
CD209 binds ICAM2 (Xenopus tropicalis)
Authored
Garapati, P V  (2015-01-05)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-09-01)
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