CD209 (DC-SIGN) acts as an adhesion molecule and besides foreign antigens (Ags), it binds to a number of endogenous ligands, particularly to intracellular adhesion molecule 2 (ICAM2) on endothelial cells. This CD209-ICAM2 interaction regulates chemokine-induced transmigration of dendritic cells across both resting and activated endothelium (Geijtenbeek et al. 2000).
van Kooyk, Y, Krooshoop, DJ, van Duijnhoven, GC, Bleijs, DA, Figdor, CG, Geijtenbeek, TB, van Vliet, SJ, Alon, R, Grabovsky, V
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