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C-type lectin receptors (CLRs)
Stable Identifier
R-HSA-5621481
DOI
10.3180/REACT_355140.1
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1,
Hepatitis C Virus,
Candida albicans,
Mycobacterium tuberculosis
Compartment
cytosol
,
nucleoplasm
,
plasma membrane
ReviewStatus
5/5
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
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Pathogen recognition is central to the induction of T cell differentiation. Groups of pathogens share similar structures known as pathogen-associated molecular patterns (PAMPs), which are recognised by pattern recognition receptors (PRRs) expressed on dendritic cells (DCs) to induce cytokine expression. PRRs include archetypical Toll-like receptors (TLRs) and non-TLRs such as retinoic acid-inducible gene I (RIG-I)-like receptors, C-type lectin receptors (CLRs) and intracellular nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs). PRR recognition of PAMPs can lead to the activation of intracellular signalling pathways that elicit innate responses against pathogens and direct the development of adaptive immunity.
CLRs comprises a large family of receptors which bind carbohydrates, through one or more carbohydrate recognition domains (CRDs), or which possess structurally similar C-type lectin-like domains (CTLDs) which do not necessarily recognise carbohydrate ligands. Some CLRs can induce signalling pathways that directly activate nuclear factor-kB (NF-kB), whereas other CLRs affect signalling by Toll-like receptors. These signalling pathways trigger cellular responses, including phagocytosis, DC maturation, chemotaxis, the respiratory burst, inflammasome activation, and cytokine production.
Literature References
PubMed ID
Title
Journal
Year
19521399
Signalling through C-type lectin receptors: shaping immune responses
Geijtenbeek, TB
,
Gringhuis, SI
Nat. Rev. Immunol.
2009
24330199
Signalling C-type lectin receptors, microbial recognition and immunity
Hoving, JC
,
Brown, GD
,
Wilson, GJ
Cell. Microbiol.
2014
Participants
Events
CLEC7A (Dectin-1) signaling
(Homo sapiens)
Dectin-2 family
(Homo sapiens)
CD209 (DC-SIGN) signaling
(Homo sapiens)
Participates
as an event of
Innate Immune System (Homo sapiens)
Event Information
Go Biological Process
stimulatory C-type lectin receptor signaling pathway (0002223)
Orthologous Events
C-type lectin receptors (CLRs) (Bos taurus)
C-type lectin receptors (CLRs) (Caenorhabditis elegans)
C-type lectin receptors (CLRs) (Canis familiaris)
C-type lectin receptors (CLRs) (Danio rerio)
C-type lectin receptors (CLRs) (Dictyostelium discoideum)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Gallus gallus)
C-type lectin receptors (CLRs) (Mus musculus)
C-type lectin receptors (CLRs) (Plasmodium falciparum)
C-type lectin receptors (CLRs) (Rattus norvegicus)
C-type lectin receptors (CLRs) (Saccharomyces cerevisiae)
C-type lectin receptors (CLRs) (Schizosaccharomyces pombe)
C-type lectin receptors (CLRs) (Sus scrofa)
C-type lectin receptors (CLRs) (Xenopus tropicalis)
Authored
Garapati, P V (2014-08-29)
Reviewed
Geijtenbeek, TB (2014-09-02)
Created
Garapati, P V (2014-08-29)
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