CLEC4C binds HIV and HCV glycoproteins

Stable Identifier
R-HSA-5621371
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Hepatitis C virus genotype 2a, Human immunodeficiency virus 1
Compartment
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CLEC4C (C-type lectin domain family 4 member C/Blood dendritic cell antigen 2 (BDCA2)) is a member of the Dectin-2 family expressed exclusively on plasmacytoid dendritic cells (pDCs). CLEC4C is capable of binding certain CD14+ monocytes, monocyte-derived DCs and several tumour cell lines by recognising sugars asialo-galactosyl-oligosaccharides with terminal beta1-4- and beta1-3-galactose residues. CLEC4C has also been shown to bind the HIV-1 envelope glycoprotein gp120 and hepatitis C virus (HCV) glycoprotein E2 (Kerscher et al. 2013, Riboldi et al. 2011, Florentin et al. 2011).
CLEC4C lacks signalling motif in its cytoplasmic tail and associates with transmembrane adapter FCERG (High affinity immunoglobulin epsilon receptor subunit gamma) to induce intracellular signal transduction in a B-cell receptor (BCR)-like fashion employing SYK to regulate the immune functions of pDCs. The FCERG-SYK signalling pathway interferes with TLR9-induced activation of pDC, inhibiting type I IFN secretion (Cao et al. 2007, Dzionek et al. 2001, Rock et al. 2007, Riboldi et al. 2011).

Literature References
PubMed ID Title Journal Year
21880719 Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides

Riboldi, E, Daniele, R, Parola, C, Inforzato, A, Arnold, PL, Bosisio, D, Fremont, DH, Bastone, A, Colonna, M, Sozzani, S

J. Biol. Chem. 2011
23053572 HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells

Florentin, J, Aouar, B, Dental, C, Thumann, C, Firaguay, G, Gondois-Rey, F, Soumelis, V, Baumert, TF, Nun├Ęs, JA, Olive, D, Hirsch, I, Stranska, R

Blood 2012
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