LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG

Stable Identifier
Reaction [transition]
Homo sapiens
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Ligation of CLEC6A (C-type lectin domain family 6 member A/Dectin-2) and CLEC4E (Mincle) with their appropriate ligands trigger the tyrosine phosphorylation of the immune receptor tyrosine-based activation motif (ITAM) in the cytoplasmic tail of FCER1G chain. Tyrosine Y65 and Y76 in the ITAM are phosphorylated and this phosphorylation is mediated by Src kinases Lyn and Fyn (Sato et al. 2006, Yamasaki et al. 2008, Quek et al. 1998).

Literature References
PubMed ID Title Journal Year
11110698 Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway

Quek, LS, Pasquet, JM, Hers, I, Cornall, R, Knight, G, Barnes, M, Hibbs, ML, Dunn, AR, Lowell, CA, Watson, SP

Blood 2000
17050534 Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses

Sato, K, Yang, XL, Yudate, T, Chung, JS, Wu, J, Luby-Phelps, K, Kimberly, RP, Underhill, D, Cruz, PD, Ariizumi, K

J. Biol. Chem. 2006
18776906 Mincle is an ITAM-coupled activating receptor that senses damaged cells

Yamasaki, S, Ishikawa, E, Sakuma, M, Hara, H, Ogata, K, Saito, T

Nat. Immunol. 2008
Participant Of
Catalyst Activity
Catalyst Activity
protein tyrosine kinase activity of FYN, LYN [cytosol]
Physical Entity
Orthologous Events
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