LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Ligation of CLEC6A (C-type lectin domain family 6 member A/Dectin-2) and CLEC4E (Mincle) with their appropriate ligands trigger the tyrosine phosphorylation of the immune receptor tyrosine-based activation motif (ITAM) in the cytoplasmic tail of FCER1G chain. Tyrosine Y65 and Y76 in the ITAM are phosphorylated and this phosphorylation is mediated by Src kinases Lyn and Fyn (Sato et al. 2006, Yamasaki et al. 2008, Quek et al. 1998).
Literature References
PubMed ID Title Journal Year
17050534 Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses

Yang, XL, Underhill, D, Kimberly, RP, Chung, JS, Sato, K, Luby-Phelps, K, Ariizumi, K, Cruz, PD, Wu, J, Yudate, T

J. Biol. Chem. 2006
11110698 Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway

Watson, SP, Dunn, AR, Hibbs, ML, Barnes, M, Knight, G, Pasquet, JM, Cornall, R, Hers, I, Quek, LS, Lowell, CA

Blood 2000
18776906 Mincle is an ITAM-coupled activating receptor that senses damaged cells

Sakuma, M, Ogata, K, Hara, H, Saito, T, Yamasaki, S, Ishikawa, E

Nat. Immunol. 2008
Catalyst Activity

protein tyrosine kinase activity of FYN, LYN [cytosol]

Orthologous Events
Cite Us!