CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM)

Stable Identifier
R-HSA-5621353
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CLEC4D (Macrophage C-type lectin (MCL)) is a member of the C-type lectin that recognises mycobacterial trehalose-6,6'-dimycolate (TDM) or cord factor likely to arise from gene duplication of CLEC4E (also called Minicle). CLEC4D is constitutively expressed on myeloid cells. It couples with FCERG (High affinity immunoglobulin epsilon receptor subunit gamma) and acts as an activating receptor (Miyake et al. 2013).

Literature References
PubMed ID Title Journal Year
23602766 C-type lectin MCL is an FcR?-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor

Miyake, Y, Toyonaga, K, Mori, D, Kakuta, S, Hoshino, Y, Oyamada, A, Yamada, H, Ono, K, Suyama, M, Iwakura, Y, Yoshikai, Y, Yamasaki, S

Immunity 2013
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Bos taurus)
CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Canis familiaris)
CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Danio rerio)
CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Mus musculus)
CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Rattus norvegicus)
CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Sus scrofa)
Authored
Garapati, P V  (2014-08-29)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-08-29)