CLEC4D (Macrophage C-type lectin (MCL)) is a member of the C-type lectin that recognises mycobacterial trehalose-6,6'-dimycolate (TDM) or cord factor likely to arise from gene duplication of CLEC4E (also called Minicle). CLEC4D is constitutively expressed on myeloid cells. It couples with FCERG (High affinity immunoglobulin epsilon receptor subunit gamma) and acts as an activating receptor (Miyake et al. 2013).
Miyake, Y, Toyonaga, K, Mori, D, Kakuta, S, Hoshino, Y, Oyamada, A, Yamada, H, Ono, K, Suyama, M, Iwakura, Y, Yoshikai, Y, Yamasaki, S
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