Reactome | CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM)

CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM)

Stable Identifier

R-HSA-5621353

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM)

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CLEC4D (Macrophage C-type lectin (MCL)) is a member of the C-type lectin that recognises mycobacterial trehalose-6,6'-dimycolate (TDM) or cord factor likely to arise from gene duplication of CLEC4E (also called Minicle). CLEC4D is constitutively expressed on myeloid cells. It couples with FCERG (High affinity immunoglobulin epsilon receptor subunit gamma) and acts as an activating receptor (Miyake et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23602766	C-type lectin MCL is an FcR?-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor Miyake, Y, Toyonaga, K, Mori, D, Kakuta, S, Hoshino, Y, Oyamada, A, Yamada, H, Ono, K, Suyama, M, Iwakura, Y, Yoshikai, Y, Yamasaki, S	Immunity	2013