CLEC6A (C-type lectin domain family 6 member A/Dectin-2 (Dendritic cell-associated C-type lectin 2)) a C-type lectin expressed by dendritic cells (DCs) and activated macrophages has been shown to bind structures with high mannose content (McGreal et al. 2006). It is reported to recognise a variety of pathogens including Candida albicans, Saccharomyces cerevisiae, Mycobacterium tuberculosis, Paracoccidioides brasiliensis, Histoplasma capsulatum, Aspergillus fumigatus, non-encapsulated Cryptococcus neoformans, Microsporum audouinii, Trichophyton rubrum, Schistosoma mansoni and house dust mite allergens (Sato et al. 2006, Gorjestani et al. 2011, Ritter et al. 2010, McGreal et al. 2006, Kerscher et al. 2013).
Like other members of the Dectin-2 family, cytoplasmic region of CLEC6A has no obvious signalling motif and it associates with transmembrane adapter FCERG (High affinity immunoglobulin epsilon receptor subunit gamma) to transduce a CLEC6A/Dectin-2 signalling.