Tyrosine-phosphorylated Phospholipase C-gamma 2 (PLCG2) translocates from the cytosol to the plasma membrane. At the membrane PLCG2 is in close proximity to phosphatidylinositol 4,5-bisphosphate (PIP2) and its other substrates generating the second messengers IP3 and DAG (Rhee 2001). This leads to the activation of CARD9-BCL10-MALT1/NF-kB signaling.
Kawakami, N, Shimohama, S, Hayakawa, T, Sumida, Y, Fujimoto, S
Rodriguez, R, Matsuda, M, Perisic, O, Bravo, J, Paul, A, Jones, NP, Light, Y, Swann, K, Williams, RL, Katan, M
© 2021 Reactome