Reactome | PLCG2 translocates from cytosol to plasma membrane

PLCG2 translocates from cytosol to plasma membrane

Stable Identifier

R-HSA-5621347

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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PLCG2 translocates from cytosol to plasma membrane

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Tyrosine-phosphorylated Phospholipase C-gamma 2 (PLCG2) translocates from the cytosol to the plasma membrane. At the membrane PLCG2 is in close proximity to phosphatidylinositol 4,5-bisphosphate (PIP2) and its other substrates generating the second messengers IP3 and DAG (Rhee 2001). This leads to the activation of CARD9-BCL10-MALT1/NF-kB signaling.

Literature References

PubMed ID	Title	Journal	Year
11606584	Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling Rodriguez, R, Matsuda, M, Perisic, O, Bravo, J, Paul, A, Jones, NP, Light, Y, Swann, K, Williams, RL, Katan, M	J Biol Chem	2001
8972730	Tyrosine phosphorylation and translocation of phospholipase C-gamma 2 in polymorphonuclear leukocytes treated with pervanadate Kawakami, N, Shimohama, S, Hayakawa, T, Sumida, Y, Fujimoto, S	Biochim. Biophys. Acta	1996