Tyrosine-phosphorylated Phospholipase C-gamma 2 (PLCG2) translocates from the cytosol to the plasma membrane. At the membrane PLCG2 is in close proximity to phosphatidylinositol 4,5-bisphosphate (PIP2) and its other substrates generating the second messengers IP3 and DAG (Rhee 2001). This leads to the activation of CARD9-BCL10-MALT1/NF-kB signaling.
Matsuda, M, Swann, K, Bravo, J, Katan, M, Jones, NP, Rodriguez, R, Williams, RL, Paul, A, Light, Y, Perisic, O
Hayakawa, T, Fujimoto, S, Kawakami, N, Sumida, Y, Shimohama, S
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