Reactome | ARF4:GTP binds VxPx-motifs of membrane proteins

ARF4:GTP binds VxPx-motifs of membrane proteins

Stable Identifier

R-HSA-5620914

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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ARF4:GTP binds VxPx-motifs of membrane proteins

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ARF4 is a small GTPase that facilitates the targeting of some membrane proteins destined for the cilium. ARF4-mediated targeting of this cargo may depend in part on a VxPx-like motif in the C-terminal tails (Deretic et al, 2005; Geng et al, 2006; Jenkins et al, 2006; Mazelova et al, 2009; Ward et al, 2011; Wang et al, 2012; reviewed in Li et al, 2012). ARF4 is the only ARF protein with a role in ciliogenesis, and its localization at the TGN positions it to act as primary sorting mechanism for membrane proteins destined for the cilium (reviewed in Deretic, 2013; Li et al, 2012). ARF4 is myristoylated at the N-terminus and is membrane-associated in its GTP-bound form (reviewed in Li et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
19153612	Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4 Mazelova, J, Astuto-Gribble, L, Inoue, H, Tam, BM, Schonteich, E, Prekeris, R, Moritz, OL, Randazzo, PA, Deretic, D	EMBO J.	2009
16537653	Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif Geng, L, Okuhara, D, Yu, Z, Tian, X, Cai, Y, Shibazaki, S, Somlo, S	J. Cell. Sci.	2006
22389062	The emerging role of Arf/Arl small GTPases in cilia and ciliopathies Li, Y, Ling, K, Hu, J	J. Cell. Biochem.	2012
16782012	Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17 Jenkins, PM, Hurd, TW, Zhang, L, McEwen, DP, Brown, RL, Margolis, B, Verhey, KJ, Martens, JR	Curr. Biol.	2006
22983554	The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting Wang, J, Morita, Y, Mazelova, J, Deretic, D	EMBO J.	2012
23567335	Crosstalk of Arf and Rab GTPases en route to cilia Deretic, D	Small GTPases	2013
21775626	A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1 Ward, HH, Brown-Glaberman, U, Wang, J, Morita, Y, Alper, SL, Bedrick, EJ, Gattone, VH, Deretic, D, Wandinger-Ness, A	Mol. Biol. Cell	2011
15728366	Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4) Deretic, D, Williams, AH, Ransom, N, Morel, V, Hargrave, PA, Arendt, A	Proc. Natl. Acad. Sci. U.S.A.	2005