ARF4:GTP binds VxPx-motifs of membrane proteins

Stable Identifier
Reaction [binding]
Homo sapiens
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ARF4 is a small GTPase that faciliates the targeting of some membrane proteins destined for the cilium. ARF4-mediated targeting of these cargo may depend in part on a VxPx-like motif in the C-terminal tails (Deretic et al, 2005; Geng et al, 2006; Jenkins et al, 2006; Mazelova et al, 2009; Ward et al, 2011; Wang et al, 2012; reviewed in Li et al, 2012). ARF4 is the only ARF protein with a role in ciliogenesis, and its localization at the TGN positions it to act as primary sorting mechanism for membrane proteins destined for the cilium (reviewed in Deretic, 2013; Li et al, 2012). ARF4 is myristoylated at the N-terminus and is membrane-associated in its GTP-bound form (reviewed in Li et al, 2012).

Literature References
PubMed ID Title Journal Year
19153612 Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4

Deretic, D, Schonteich, E, Inoue, H, Mazelova, J, Prekeris, R, Astuto-Gribble, L, Moritz, OL, Randazzo, PA, Tam, BM

EMBO J. 2009
16537653 Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif

Somlo, S, Shibazaki, S, Cai, Y, Tian, X, Yu, Z, Geng, L, Okuhara, D

J. Cell. Sci. 2006
22389062 The emerging role of Arf/Arl small GTPases in cilia and ciliopathies

Ling, K, Hu, J, Li, Y

J. Cell. Biochem. 2012
16782012 Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17

Zhang, L, Hurd, TW, Martens, JR, Brown, RL, Jenkins, PM, Verhey, KJ, McEwen, DP, Margolis, B

Curr. Biol. 2006
22983554 The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting

Deretic, D, Morita, Y, Mazelova, J, Wang, J

EMBO J. 2012
23567335 Crosstalk of Arf and Rab GTPases en route to cilia

Deretic, D

Small GTPases 2013
21775626 A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1

Alper, SL, Deretic, D, Brown-Glaberman, U, Wandinger-Ness, A, Morita, Y, Ward, HH, Bedrick, EJ, Wang, J, Gattone, VH

Mol. Biol. Cell 2011
15728366 Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4)

Williams, AH, Deretic, D, Arendt, A, Hargrave, PA, Morel, V, Ransom, N

Proc. Natl. Acad. Sci. U.S.A. 2005
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