Reactome | PAXIP1 [nucleoplasm]

PAXIP1 [nucleoplasm]

Stable Identifier

R-HSA-5619395

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PAX-interacting protein 1, PAXI1_HUMAN, PTIP

Locations in the PathwayBrowser for interactor UniProt:Q96F63 CCD97

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External Reference Information

External Reference

UniProt:Q6ZW49 PAXIP1

Gene Names

PAXIP1, PAXIP1L, PTIP, CAGF28

Chain

chain:1-1069

Reference Genes

BioGPS Gene:22976 PAXIP1

COSMIC (genes):PAXIP1 PAXIP1

CTD Gene:22976 PAXIP1

dbSNP Gene:22976 PAXIP1

ENSEMBL:ENSG00000157212 PAXIP1

HGNC:8624 PAXIP1

KEGG:hsa:22976 PAXIP1

Monarch:22976 PAXIP1

NCBI Gene:22976 PAXIP1

OMIM:608254 PAXIP1

UCSC:Q6ZW49 PAXIP1

Reference Transcript

Participates

as an input of

as a component of

as an output of

Association of Ku heterodimer with ends of DNA double-strand break (Homo sapiens)

Inferred To

Homologues of PAXIP1 [nucleoplasm] (Drosophila melanogaster)

PAXIP1 [nucleoplasm] (Bos taurus)

PAXIP1 [nucleoplasm] (Canis familiaris)

PAXIP1 [nucleoplasm] (Gallus gallus)

PAXIP1 [nucleoplasm] (Sus scrofa)

Paxip1 [nucleoplasm] (Mus musculus)

Paxip1 [nucleoplasm] (Rattus norvegicus)

mu2 [nucleoplasm] (Drosophila melanogaster)

paxip1 [nucleoplasm] (Danio rerio)

Ghost homologue of PAXIP1 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of PAXIP1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of PAXIP1 [nucleoplasm] (Schizosaccharomyces pombe)

Ptip [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_031375.3, XP_047276013.1, XP_054213611.1, XP_054213613.1, XP_005249596.1, XP_016867370.1, XP_047276015.1

OpenTargets

ENSG00000157212

ENSEMBL

ENSP00000384048, ENSG00000157212, ENST00000404141

HPA

ENSG00000157212-PAXIP1

GeneCards

PAXIP1

PRO

Q6ZW49

Pharos - Targets

Q6ZW49

GlyGen

Q6ZW49

PDB

3SQD

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.899	11
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.84	13
UniProt:Q9BTK6 PAGR1	1	PAGR1 [nucleoplasm] (R-HSA-5619374)	0.794	10
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.788	10
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.773	13
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.656	5
UniProt:O15550 KDM6A	1	KDM6A [nucleoplasm] (R-HSA-4754224)	0.643	8
UniProt:O14686 KMT2D	20	KMT2D R5471M [nucleoplasm] (R-HSA-9946506) KMT2D W5217R [nucleoplasm] (R-HSA-9946443) KMT2D H5059P [nucleoplasm] (R-HSA-9945069) KMT2D R5340Q [nucleoplasm] (R-HSA-9946447) KMT2D R3321* [nucleoplasm] (R-HSA-9949952) KMT2D E5425K [nucleoplasm] (R-HSA-9946502) KMT2D Y5510D [nucleoplasm] (R-HSA-9946521) KMT2D M999Yfs69 [nucleoplasm] (R-HSA-9949980) KMT2D K1885Qfs18 [nucleoplasm] (R-HSA-9949981) KMT2D G5189R [nucleoplasm] (R-HSA-9946430) KMT2D T5098P [nucleoplasm] (R-HSA-9946431) KMT2D R2635* [nucleoplasm] (R-HSA-9949939) KMT2D R3707* [nucleoplasm] (R-HSA-9949940) KMT2D R5027* [nucleoplasm] (R-HSA-9949941) KMT2D E5008* [nucleoplasm] (R-HSA-9949943) KMT2D L449Vfs5 [nucleoplasm] (R-HSA-9952106) KMT2D Q2004 [nucleoplasm] (R-HSA-9951082) KMT2D I1509Vfs6 [nucleoplasm] (R-HSA-9952107) KMT2D R1687Tfs4 [nucleoplasm] (R-HSA-9952109) KMT2D Q4230* [nucleoplasm] (R-HSA-9951085)	0.643	8
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.527	2
UniProt:Q96F63 CCD97			0.527	2

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