Variant SLC6A14 may confer susceptibility towards obesity

Stable Identifier
Homo sapiens
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SLC6A14 mediates the uptake of multiple basic and nonpolar amino acids as well as beta-alanine across the plasma membrane. Uptake of one amino acid molecule is accompanied by uptake of two sodium ions and a chloride ion (Broer & Gether 2012, Schweikhard & Ziegler 2012). As assessed by Northern blotting, SLC6A14 is expressed at high levels in lung but only at low levels, if at all, in intestine or kidney. Variations in SLC6A14 may be associated with obesity (BMIQ11; MIM:300306) in some populations. SLC6A14 is an interesting candidate for obesity because it may potentially regulate tryptophan availability for serotonin synthesis and thus could affect appetite control (Suviolahti et al. 2003, Durand et al. 2004).

Literature References
PubMed ID Title Journal Year
15331564 Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians

Durand, E, Dina, C, Meyre, D, Boutin, P, Charles, MA, Clément, K, Froguel, P

Diabetes 2004
22519513 The solute carrier 6 family of transporters

Gether, U, Broer, S

Br. J. Pharmacol. 2012
23177982 Amino acid secondary transporters: toward a common transport mechanism

Schweikhard, ES, Ziegler, CM

Curr Top Membr 2012
14660752 The SLC6A14 gene shows evidence of association with obesity

Salomaa, V, Silander, K, Groop, L, Kontula, K, Kilpikari, R, Tuomi, T, Kaprio, J, Vartiainen, E, Ridderstrale, M, Cantor, RM, Ohman, M, Rissanen, A, Suviolahti, E, Oksanen, LJ, Pajukanta, P, Mustajoki, P, Jousilahti, P, Peltonen, L

J. Clin. Invest. 2003
Name Identifier Synonyms
obesity DOID:9970
Cross References
BioModels Database
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