Reactome | HDAC6 deacetylates microtubules

HDAC6 deacetylates microtubules

Stable Identifier

R-HSA-5618331

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

4/5

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HDAC6 is a microtubule-associated deacetylase that targets the K40 acetyl groups of alpha tubulin (Hubbert et al, 2002; Loktev et al, 2008; Zhang et al, 2008). HDAC6 also interacts with BBIP1, a component of the BBSome that is required for BBSome assembly, and additionally (and independently of its role in the BBSome) plays a role in microtubule polymerization and acetylation (Loktev et al, 2008). Depletion of BBIP1 causes a marked reduction in cytoplasmic microtubule acetylation, and this defect is partially overcome by inhibition of HDAC6. These data suggest that BBIP1 may exert its effect on microtubule acetylation by negatively regulating HDAC6, although other mechanisms are also possible (Loktev et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
19081074	A BBSome subunit links ciliogenesis, microtubule stability, and acetylation Scheetz, TE, Searby, CC, Loktev, AV, Zhang, Q, Sheffield, VC, Nachury, MV, Slusarski, DC, Jackson, PK, Beck, JS, Bazan, JF	Dev. Cell	2008
18180281	Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally Yamaguchi, T, Matthias, G, Khochbin, S, Mizeracki, A, Alt, FW, Matthias, P, Cubizolles, F, Li, N, Kwon, S, Kneissel, M, Zhang, Y, Cao, C, Chua, K, Cheng, HL, Lombard, D, Rousseaux, S	Mol. Cell. Biol.	2008
12024216	HDAC6 is a microtubule-associated deacetylase Nixon, A, Wang, XF, Yoshida, M, Shao, R, Guardiola, A, Hubbert, C, Yao, TP, Ito, A, Kawaguchi, Y	Nature	2002