Assembly of IFT A complex

Stable Identifier
R-HSA-5617829
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The IFT A complex is believed to be composed of six components: WDR19/IFT144, IFT140, IFT122, TTC21B/IFT139, WDR35/IFT121 and IFT43 (Piperno et al, 1998; Cole and Snell, 2009; reviewed in Taschner et al, 2012). Each of these proteins was identified as a TULP3-interacting protein in human cells, supporting the notion established in other organisms that they are all components of the IFT A complex (Mukhopadhyay et al, 2010; reviewed in Taschner et al, 2012). The IFT A proteins are large and generally have similar domain organization, consisting of N-terminal WD motifs and C-terminal TPR repeats. These protein interaction domains may help the IFT A complex scaffold recruitment of the IFT B complex, as well as recruit ciliary cargo and motor proteins. Intriguingly, the domain structure of IFT A proteins is similar to that of nucleoporins and coat proteins and it has been suggested that they evolved from a coat protein precursor, consistent with a role in vesicle trafficking (Devos et al, 2004; Jekely and Arendt, 2006).
Details of protein-protein interactions within the IFT A complex are not known, nor are the details of how and where the complex assembles in a human cell.

Literature References
PubMed ID Title Journal Year
19450523 SnapShot: Intraflagellar transport

Cole, DG, Snell, WJ

Cell 2009
15523559 Components of coated vesicles and nuclear pore complexes share a common molecular architecture

Devos, D, Dokudovskaya, S, Alber, F, Williams, R, Chait, BT, Sali, A, Rout, MP

PLoS Biol. 2004
9852153 Distinct mutants of retrograde intraflagellar transport (IFT) share similar morphological and molecular defects

Piperno, G, Siuda, E, Henderson, S, Segil, M, Vaananen, H, Sassaroli, M

J. Cell Biol. 1998
20889716 TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

Mukhopadhyay, S, Wen, X, Chih, B, Nelson, CD, Lane, WS, Scales, SJ, Jackson, PK

Genes Dev. 2010
16435301 Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium

Jékely, G, Arendt, D

Bioessays 2006
22118932 Architecture and function of IFT complex proteins in ciliogenesis

Taschner, M, Bhogaraju, S, Lorentzen, E

Differentiation 2012
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