Reactome | Assembly of IFT A complex

Assembly of IFT A complex

Stable Identifier

R-HSA-5617829

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cilium

ReviewStatus

5/5

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The IFT A complex is believed to be composed of six components: WDR19/IFT144, IFT140, IFT122, TTC21B/IFT139, WDR35/IFT121 and IFT43 (Piperno et al, 1998; Cole and Snell, 2009; reviewed in Taschner et al, 2012). Each of these proteins was identified as a TULP3-interacting protein in human cells, supporting the notion established in other organisms that they are all components of the IFT A complex (Mukhopadhyay et al, 2010; reviewed in Taschner et al, 2012). The IFT A proteins are large and generally have similar domain organization, consisting of N-terminal WD motifs and C-terminal TPR repeats. These protein interaction domains may help the IFT A complex scaffold recruitment of the IFT B complex, as well as recruit ciliary cargo and motor proteins. Intriguingly, the domain structure of IFT A proteins is similar to that of nucleoporins and coat proteins and it has been suggested that they evolved from a coat protein precursor, consistent with a role in vesicle trafficking (Devos et al, 2004; Jekely and Arendt, 2006).
Details of protein-protein interactions within the IFT A complex are not known, nor are the details of how and where the complex assembles in a human cell.

Literature References

PubMed ID	Title	Journal	Year
15523559	Components of coated vesicles and nuclear pore complexes share a common molecular architecture Devos, D, Dokudovskaya, S, Alber, F, Williams, R, Chait, BT, Sali, A, Rout, MP	PLoS Biol.	2004
19450523	SnapShot: Intraflagellar transport Cole, DG, Snell, WJ	Cell	2009
9852153	Distinct mutants of retrograde intraflagellar transport (IFT) share similar morphological and molecular defects Piperno, G, Siuda, E, Henderson, S, Segil, M, Vaananen, H, Sassaroli, M	J. Cell Biol.	1998
20889716	TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia Mukhopadhyay, S, Wen, X, Chih, B, Nelson, CD, Lane, WS, Scales, SJ, Jackson, PK	Genes Dev.	2010
16435301	Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium Jékely, G, Arendt, D	Bioessays	2006
22118932	Architecture and function of IFT complex proteins in ciliogenesis Taschner, M, Bhogaraju, S, Lorentzen, E	Differentiation	2012