Reactome | RAB3IP stimulates nucleotide exchange on RAB8A

RAB3IP stimulates nucleotide exchange on RAB8A

Stable Identifier

R-HSA-5617816

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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RAB3IP stimulates nucleotide exchange on RAB8A

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RAB3IP is a GEF for RAB8A, the only RAB GTPase localized in the cilium. GTP-bound RAB8A may play a role in recruiting vesicles from the Golgi to the ciliary base and is required for cilia formation (Nachury et al, 2007; Yoshimura et al, 2007; reviewed in Reiter et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
22653444	The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization Reiter, JF, Blacque, OE, Leroux, MR	EMBO Rep.	2012
17646400	Functional dissection of Rab GTPases involved in primary cilium formation Yoshimura, S, Egerer, J, Fuchs, E, Haas, AK, Barr, FA	J. Cell Biol.	2007
17574030	A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis Nachury, MV, Loktev, AV, Zhang, Q, Westlake, CJ, Peränen, J, Merdes, A, Slusarski, DC, Scheller, RH, Bazan, JF, Sheffield, VC, Jackson, PK	Cell	2007