Reactome | ARL6 [cilium]

ARL6 [cilium]

Stable Identifier

R-HSA-5617766

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cilium

Synonyms

BBS3

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - BBSome-mediated cargo-targeting to cilium (Homo sapiens)
      - ARL6:GTP and the BBSome target cargo to the primary cilium (Homo sapiens)
        
        ARL6:GTP:BBSome:ciliary cargo [ciliary membrane] (Homo sapiens)
        
        ARL6:GTP [cilium] (Homo sapiens)
        
        ARL6 [cilium] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H0F7 ARL6

Gene Names

ARL6, BBS3

Chain

initiator methionine:1, chain:2-186

Reference Genes

BioGPS Gene:84100 ARL6

COSMIC (genes):ARL6 ARL6

CTD Gene:84100 ARL6

dbSNP Gene:84100 ARL6

ENSEMBL:ENSG00000113966 ARL6

HGNC:13210 ARL6

KEGG:hsa:84100 ARL6

Monarch:84100 ARL6

NCBI Gene:84100 ARL6

OMIM:608845 ARL6

UCSC:Q9H0F7 ARL6

Reference Transcript

Participates

as a component of

ARL6:GTP [cilium] (Homo sapiens)

Other forms of this molecule

ARL6 [plasma membrane]

Inferred To

arl6 [cilium] (Danio rerio)

arl6 [cilium] (Xenopus tropicalis)

arl-6 [cilium] (Caenorhabditis elegans)

Arl6 [cilium] (Drosophila melanogaster)

Arl6 [cilium] (Mus musculus)

Arl6 [cilium] (Rattus norvegicus)

ARL6 [cilium] (Bos taurus)

ARL6 [cilium] (Canis familiaris)

ARL6 [cilium] (Sus scrofa)

Cross References

RefSeq

NP_001265222.1, NP_115522.1, XP_054204056.1, NP_816931.1, NP_001310442.1, XP_016862800.1

ENSEMBL

ENSG00000113966, ENSP00000419619, ENST00000493990, ENSP00000488530, ENSP00000337722, ENST00000463745, ENST00000462412, ENST00000631834, ENSP00000418740, ENST00000335979, ENSP00000418057

OpenTargets

ENSG00000113966

GeneCards

ARL6

HPA

ENSG00000113966-ARL6

PRO

Q9H0F7

Pharos - Targets

Q9H0F7

Orphanet

ARL6

PDB

2H57

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NFJ9 BBS1	1	BBS1 [cytosol] (R-HSA-5617640)	0.649	4
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.508	2
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.462	3
UniProt:Q9BXC9 BBS2	1	BBS2 [cytosol] (R-HSA-5617637)	0.462	3

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