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HOXA3 gene is transcribed
Stable Identifier
R-HSA-5617676
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
,
nucleoplasm
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Activation of HOX genes during differentiation (Homo sapiens)
Activation of anterior HOX genes in hindbrain development during early embryogenesis (Homo sapiens)
HOXA3 gene is transcribed (Homo sapiens)
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The HOXA3 gene is transcribed to yield mRNA (Han et al. 2007). In mouse embryos Hoxa3 mRNA is observed in rhombomere 5 and caudally through the central nervous system, ectoderm, and somitic mesoderm. HOXA3 mRNA is a target of the microRNA miR-10a (Han et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
17660710
DNA methylation regulates MicroRNA expression
Sukumar, S
,
Han, L
,
Valle, D
,
Casey, E
,
Witmer, PD
Cancer Biol. Ther.
2007
Participants
Input
HOXA3 gene [nucleoplasm]
(Homo sapiens)
Output
HOXA3 mRNA [cytosol]
(Homo sapiens)
Participates
as an event of
Activation of anterior HOX genes in hindbrain development during early embryogenesis (Homo sapiens)
This event is regulated
Positively by
Regulator
MAFB, HOXB1:PBX1:PKNOX1 at active HOXA3 chromatin [nucleoplasm]
(Homo sapiens)
Active Unit
CTCF [nucleoplasm]
MLL3,4 complex [nucleoplasm]
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
MAFB [nucleoplasm]
Inferred From
Hoxa3 gene is transcribed (Mus musculus)
Authored
Rezsohazy, R (2015-11-15)
May, B (2014-08-08)
Reviewed
Blasi, F (2015-05-13)
Created
May, B (2014-08-13)
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