HOXB3 gene is transcribed

Stable Identifier
R-HSA-5617672
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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HOXB3 gene is transcribed
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The HOXB3 gene is transcribed to yield mRNA (in embryos in Giampaolo et al. 1989, in carcinoma cells in Simeone et al. 1990). The HOXB3 mRNA is a target of the microRNAs miR-7 and miR-218 in breast cancer cells (Li et al. 2012) and miR-10A (Weiss et al. 2009). In mouse embryos Hoxb3 mRNA is observed strongly in rhombomere 5 and more weakly in rhombomeres 6 and 7 of the hindbrain. Hoxb3 mRNA is also observed in mesodermal derivatives including lung, stomach, pancreas, and metanephros, and in neural crest derivatives.
Literature References
PubMed ID Title Journal Year
2570724 Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system

Russo, G, Acampora, D, Pannese, M, Faiella, A, D'Esposito, M, Zappavigna, V, Giampaolo, A, Stornaiuolo, A, Simeone, A, Carè, A

Differentiation 1989
19747919 Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer

Marques, IJ, Woltering, JM, Bagowski, CP, Aghdassi, A, Weiss, FU, Partecke, LI, Heidecke, CD, Lerch, MM, Vlecken, DH

Gastroenterology 2009
22705304 miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

Zhu, F, Li, Q, Chen, P

Biochem. Biophys. Res. Commun. 2012
1975088 Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

Acampora, D, Mavilio, F, Boncinelli, E, Arcioni, L, Andrews, PW, Simeone, A

Nature 1990
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm] (Homo sapiens)
Active Unit
EGR2 [nucleoplasm]
MLL3,4 complex [nucleoplasm]
MAFB:JUN [nucleoplasm]
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
Inferred From
Hoxb3 gene is transcribed (Mus musculus)
Authored
Rezsohazy, R  (2015-11-15)
May, B  (2014-08-08)
Reviewed
Blasi, F  (2015-05-13)
Created
May, B  (2014-08-13)
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