Reactome | HOXB3 mRNA is translated

HOXB3 mRNA is translated

Stable Identifier

R-HSA-5617668

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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HOXB3 mRNA is translated to yield HOXB3 protein (Palakurthy et al. 2009, Li et al. 2012, Chen et al. 2013). Translation is repressed by the microRNAs miR-7 and miR-218 (Li et al. 2012) and miR-10A (Weiss et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19747919	Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer Marques, IJ, Woltering, JM, Bagowski, CP, Aghdassi, A, Weiss, FU, Partecke, LI, Heidecke, CD, Lerch, MM, Vlecken, DH	Gastroenterology	2009
22705304	miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer Zhu, F, Li, Q, Chen, P	Biochem. Biophys. Res. Commun.	2012
19854132	Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression Gobeil, S, Wajapeyee, N, Gazin, C, Santra, MK, Green, MR, Palakurthy, RK, Lin, L	Mol. Cell	2009
23219899	HoxB3 promotes prostate cancer cell progression by transactivating CDCA3 Shang, Z, Jiang, N, Niu, Y, Quan, C, Zhu, S, Chen, J	Cancer Lett.	2013