Reactome | HSPB11 [cilium]

HSPB11 [cilium]

Stable Identifier

R-HSA-5617628

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cilium

Synonyms

IFT25, IFT-B 25, IFT B

Locations in the PathwayBrowser for interactor UniProt:Q96SB8 SMC6

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External Reference Information

External Reference

UniProt:Q9Y547 HSPB11

Gene Names

HSPB11, C1orf41, IFT25, HSPC034

Chain

chain:1-144

Reference Genes

BioGPS Gene:51668 HSPB11

COSMIC (genes):HSPB11 HSPB11

CTD Gene:51668 HSPB11

dbSNP Gene:51668 HSPB11

ENSEMBL:ENSG00000081870 HSPB11

HGNC:25019 HSPB11

Monarch:51668 HSPB11

NCBI Gene:51668 HSPB11

OMIM:620841 HSPB11

UCSC:Q9Y547 HSPB11

Reference Transcript

Other Identifiers

11719697_a_at

11719698_x_at

16687467

203960_PM_s_at

203960_s_at

215691_PM_x_at

215691_x_at

2413520

2413521

2413522

2413523

2413526

2413527

2413528

2413531

2413532

2413533

2413534

2413535

2413538

2413539

2413540

2413542

36032_at

51668

7916356

A_23_P96872

A_33_P3295173

A_33_P3295178

GE63151

GO:0001501

GO:0001822

GO:0005515

GO:0005813

GO:0005815

GO:0005929

GO:0007018

GO:0007224

GO:0007283

GO:0007507

GO:0015031

GO:0022414

GO:0030154

GO:0030324

GO:0030992

GO:0035720

GO:0042073

GO:0043226

GO:0044782

GO:0046872

GO:0048856

GO:0060271

GO:0070986

GO:0097542

HMNXSV003031289

HMNXSV003047100

HMNXSV003057347

Hs.46967.1.S1_3p_x_at

ILMN_1681340

PH_hs_0020864

TC01005500.hg

g7706382_3p_a_at

Participates

as an input of

Assembly of IFT B complex (Homo sapiens)

as a component of

IFT B* [cilium] (Homo sapiens)

Other forms of this molecule

HSPB11 [ciliary tip]

Inferred To

IFT25 [cilium] (Bos taurus)

IFT25 [cilium] (Canis familiaris)

IFT25 [cilium] (Sus scrofa)

HSPB11 [cilium] (Gallus gallus)

HSPB11 [cilium] (Mus musculus)

Ghost homologue of HSPB11 [cilium] (Caenorhabditis elegans)

Ift25 [cilium] (Rattus norvegicus)

Cross References

ENSEMBL

ENSP00000194214, ENST00000194214

OpenTargets

ENSG00000081870

HPA

ENSG00000081870-HSPB11

PRO

Q9Y547

Pharos - Targets

Q9Y547

PDB

1XPW, 1TVG

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BW83 IFT27	2	IFT27 [ciliary tip] (R-HSA-5625357) IFT27 [cilium] (R-HSA-5617621)	0.943	24
UniProt:Q9H7X7 IFT22	2	RABL5 [cilium] (R-HSA-5617605) RABL5 [ciliary tip] (R-HSA-5625388)	0.725	6
UniProt:Q13099 IFT88	8	PolyUb-Misfolded IFT88 [lysosomal lumen] (R-HSA-9660026) PolyUb-Misfolded IFT88 [cytosol] (R-HSA-9641125) Ub-Misfolded IFT88 [cytosol] (R-HSA-9641114) Misfolded IFT88 [cytosol] (R-HSA-9640115) Misfolded IFT88 [cilium] (R-HSA-9640106) IFT88 [cilium] (R-HSA-5610385) PolyUb-Misfolded IFT88 [late endosome lumen] (R-HSA-9660031) IFT88 [ciliary tip] (R-HSA-5625371)	0.724	6
UniProt:Q9Y366 IFT52	2	IFT52 [ciliary tip] (R-HSA-5625360) IFT52 [cilium] (R-HSA-5610387)	0.69	7
UniProt:Q9NQC8 IFT46	2	IFT46 [ciliary tip] (R-HSA-5625359) IFT46 [cilium] (R-HSA-5617617)	0.69	6
UniProt:Q8WYA0 IFT81	2	IFT81 [cilium] (R-HSA-5617769) IFT81 [ciliary tip] (R-HSA-5625369)	0.69	6
UniProt:A0AVF1 TTC26	2	TTC26 [ciliary tip] (R-HSA-5637962) TTC26 [cilium] (R-HSA-5637963)	0.69	7
UniProt:Q96LB3 IFT74	2	IFT74 [ciliary tip] (R-HSA-5625364) IFT74 [cilium] (R-HSA-5617616)	0.69	7
UniProt:Q9UG01 IFT172	2	IFT172 [ciliary tip] (R-HSA-5625353) IFT172 [cilium] (R-HSA-5610383)	0.69	5
UniProt:Q86WT1 IFT70A	2	TTC30A [ciliary tip] (R-HSA-5637966) TTC30A [cilium] (R-HSA-5637968)	0.638	3
UniProt:Q8IY31 IFT20	3	IFT20 [ciliary tip] (R-HSA-5625355) IFT20 [Golgi membrane] (R-HSA-5617625) IFT20 [cilium] (R-HSA-5617624)	0.638	5
UniProt:Q9H8Y8 GORASP2	2	p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965) GORASP2 [Golgi membrane] (R-HSA-2422385)	0.556	3
UniProt:Q9Y6Y8 SEC23IP	2	SEC23IP [cytosol] (R-HSA-5688156) SEC23IP [COPII-coated ER to Golgi transport vesicle] (R-HSA-5688153)	0.556	3
UniProt:Q13114 TRAF3	4	K63polyUb-TRAF3 [cytosol] (R-HSA-936402) TRAF3 [cytosol] (R-HSA-914241) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 R118W [cytosol] (R-HSA-5602321)	0.556	3
UniProt:Q9NWB7 IFT57	2	IFT57 [cilium] (R-HSA-5610389) IFT57 [ciliary tip] (R-HSA-5625363)	0.527	4
UniProt:Q96SB8 SMC6	1	SMC6 [nucleoplasm] (R-HSA-2993777)	0.508	2
UniProt:Q86VQ0 LCA5			0.508	2
UniProt:Q9P2H3 IFT80	2	IFT80 [ciliary tip] (R-HSA-5625367) IFT80 [cilium] (R-HSA-5617613)	0.508	2

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