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TTC8 [cytosol]
Stable Identifier
R-HSA-5617600
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
BBS8
GO Cellular Component
ciliary basal body
(0036064)
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
BBSome-mediated cargo-targeting to cilium (Homo sapiens)
ARL6:GTP and the BBSome bind ciliary cargo (Homo sapiens)
ARL6:GTP:BBSome:ciliary cargo [plasma membrane] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
TTC8 [cytosol] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
TTC8 [cytosol] (Homo sapiens)
ARL6:GTP and the BBSome target cargo to the primary cilium (Homo sapiens)
ARL6:GTP:BBSome:ciliary cargo [ciliary membrane] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
TTC8 [cytosol] (Homo sapiens)
ARL6:GTP:BBSome:ciliary cargo [plasma membrane] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
TTC8 [cytosol] (Homo sapiens)
LZTFL1 oligomer:BBSome [cytosol] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
TTC8 [cytosol] (Homo sapiens)
BBSome binds RAB3IP (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
TTC8 [cytosol] (Homo sapiens)
RAB3IP:BBSome [ciliary basal body] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
TTC8 [cytosol] (Homo sapiens)
Formation of the BBSome (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
TTC8 [cytosol] (Homo sapiens)
TTC8 [cytosol] (Homo sapiens)
LZTFL1 binds the BBSome and prevents its traffic to the cilium (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
TTC8 [cytosol] (Homo sapiens)
LZTFL1 oligomer:BBSome [cytosol] (Homo sapiens)
BBSome [cytosol] (Homo sapiens)
TTC8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TAM2 TTC8
Gene Names
TTC8, BBS8
Chain
chain:1-541
Reference Genes
BioGPS Gene:123016 TTC8
COSMIC (genes):TTC8 TTC8
CTD Gene:123016 TTC8
dbSNP Gene:123016 TTC8
ENSEMBL:ENSG00000165533 TTC8
ENSEMBL:ENSG00000165533.19 TTC8
HGNC:20087 TTC8
KEGG Gene (Homo sapiens):123016 TTC8
Monarch:123016 TTC8
NCBI Gene:123016 TTC8
OMIM:608132 TTC8
UCSC:Q8TAM2 TTC8
Reference Transcript
RefSeq:NM_001288783.1 TTC8
RefSeq:NM_198309.3 TTC8
RefSeq:XM_006720035.1 TTC8
RefSeq:XM_011536432.1 TTC8
RefSeq:NM_001288782.1 TTC8
RefSeq:NM_144596.3 TTC8
RefSeq:NM_198310.3 TTC8
RefSeq:NM_001288781.1 TTC8
RefSeq:XM_006720037.2 TTC8
Other Identifiers
11732095_a_at
11744591_a_at
11748573_a_at
123016
16787314
226120_PM_at
226120_at
3547698
3547699
3547700
3547705
3547706
3547709
3547710
3547712
3547717
3547724
3547725
3547726
3547727
3547728
3547729
3547730
3547731
3547734
3547736
3547737
62208_r_at
7976128
A_14_P130318
A_14_P139522
A_32_P169735
GE88360
GO:0001736
GO:0005515
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005929
GO:0007010
GO:0007163
GO:0007411
GO:0007608
GO:0015031
GO:0016020
GO:0021772
GO:0030030
GO:0030154
GO:0032391
GO:0032880
GO:0034260
GO:0034464
GO:0035264
GO:0036064
GO:0042995
GO:0043226
GO:0044782
GO:0045198
GO:0045444
GO:0048560
GO:0048856
GO:0050877
GO:0050893
GO:0051492
GO:0060122
GO:0060170
GO:0060219
GO:0060271
GO:0061326
GO:0061629
GO:0072659
GO:0097730
GO:1903251
GO:1905515
HMNXSV003005164
Hs.55158.0.A1_3p_at
ILMN_1652309
PH_hs_0031249
TC14000538.hg
Participates
as an input of
Formation of the BBSome (Homo sapiens)
as a component of
BBSome [cytosol] (Homo sapiens)
Inferred To
Ghost homologue of TTC8 [cytosol]
(Danio rerio)
Ttc8 [cytosol]
(Mus musculus)
Ttc8 [cytosol]
(Rattus norvegicus)
bbs-8 [cytosol]
(Caenorhabditis elegans)
ttc8 [cytosol]
(Xenopus tropicalis)
TTC8 [cytosol]
(Bos taurus)
TTC8 [cytosol]
(Canis familiaris)
TTC8 [cytosol]
(Gallus gallus)
TTC8 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_653197.2
,
XP_006720098.1
,
NP_001275712.1
,
NP_001275710.1
,
NP_938052.1
,
NP_001275711.1
,
XP_011534734.1
,
NP_938051.1
,
XP_006720100.1
OpenTargets
ENSG00000165533
HPA
ENSG00000165533-TTC8
GeneCards
Q8TAM2
Ensembl
ENST00000354441
,
ENSP00000370031
,
ENST00000380656
,
ENSG00000165533
,
ENSP00000346427
PRO
Q8TAM2
Pharos - Targets
Q8TAM2
Orphanet
15671
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96RK4 BBS4
1
BBS4 [cytosol]
(R-HSA-5617635)
0.789
5
UniProt:Q8NFJ9 BBS1
1
BBS1 [cytosol]
(R-HSA-5617640)
0.771
5
UniProt:Q8N3I7 BBS5
1
BBS5 [cytosol]
(R-HSA-5617633)
0.725
4
UniProt:Q8IWZ6 BBS7
1
BBS7 [cytosol]
(R-HSA-5617632)
0.638
3
UniProt:Q9BXC9 BBS2
1
BBS2 [cytosol]
(R-HSA-5617637)
0.638
4
UniProt:Q15051 IQCB1
1
IQCB1 [cytosol]
(R-HSA-5626648)
0.571
5
UniProt:Q3SYG4 BBS9
1
BBS9 [cytosol]
(R-HSA-5617630)
0.534
3
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