HOXA1 gene is transcribed

Stable Identifier
R-HSA-5617471
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
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HOXA1 gene is transcribed
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CNOT6 (CCR4) and ZNF335 (NIF-1) directly associate and indirectly enhance the transcription of HOXA1 produced by activation by retinoic acid (Garapaty et al. 2008)

After activation by retinoic acid, the HOXA1 gene is transcribed to yield mRNA (inferred from mouse embryos, also demonstrated in human cancer cells, Chariot et al. 1995, Xu et al. 2014). The mRNA is a target of the microRNAs miR-10a in megakaryocytes (Garzon et al. 2006), miR210 in tumors (Huang et al. 2009), let-7c in non-small cell lung cancer cells (Zhan et al. 2013), miR-99 in epithelial cells (Chen et al. 2013), and miR-100 in tumor cells (Chen et al. 2014), however it is unknown if these play a role in embryogenesis. Opposite strand intergenic transcripts are also observed in adult tissues and placenta (Sessa et al. 2007).
In mouse embryos, expression of Hoxa1 occurs in the neural tube, adjacent mesenchyme, paraxial mesoderm, somites, and gut epithelium from rhombomere 4 to the caudal-most region of the embryo. (Rhombomeres are transiently formed segments in the neural tube that will eventually form the hindbrain.)

Regulation of HOXA1 by retinoic acid is inferred from mouse embryos (Frasch et al. 1995, Dupe et al. 1997, Paschaki et al. 2013) and cell lines (Langston and Gudas 1992, Langston et al. 1997, Gillespie and Gudas 2007).

RQCD1 (RCD1) enhances transcription of the HOXA1 in response to activation by retinoic acid (Garapaty et al. 2008).

Literature References
PubMed ID Title Journal Year
19115252 The truncated Hoxa1 protein interacts with Hoxa1 and Pbx1 in stem cells

Gudas, LJ, Fernandez, CC

J. Cell. Biochem. 2009
24586203 miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion

Yuan, Y, Liang, H, Gupta, S, Sun, Y, Wang, M, Zhang, P, Teruya-Feldstein, J, Zhang, J, Ma, L, Han, Z, Chen, D, You, MJ, Hung, MC

PLoS Genet. 2014
23534758 Let-7c inhibits NSCLC cell proliferation by targeting HOXA1

Yu, J, Qu, Q, Wang, G, Tan, SL, Lou, XY, Liu, YZ, Zhou, HH, Zhan, M

Asian Pac. J. Cancer Prev. 2013
25135475 CTCF Controls HOXA Cluster Silencing and Mediates PRC2-Repressive Higher-Order Chromatin Structure in NT2/D1 Cells

Wang, J, Lv, X, Liu, G, Liang, CC, Zhao, GN, Xu, M, Liu, DP, Hao, DL, Wang, LY

Mol. Cell. Biol. 2014
16549775 MicroRNA fingerprints during human megakaryocytopoiesis

Iuliano, R, Aqeilan, RI, Croce, CM, Cimmino, A, Garzon, R, Calin, GA, Andreeff, M, Liu, CG, Palumbo, T, Marcucci, G, Bhatt, D, Alder, H, Volinia, S, Pichiorri, F, Bloomfield, CD

Proc. Natl. Acad. Sci. U.S.A. 2006
24312487 MicroRNA-99 family members suppress Homeobox A1 expression in epithelial cells

Adjei, BS, Zhang, L, Wang, A, Jin, Y, Chen, Z, Chen, D, Dragas, D, Zhou, X, Dai, Y

PLoS ONE 2013
7488013 Retinoic acid induces three newly cloned HOXA1 transcripts in MCF7 breast cancer cells

Chariot, A, Sobel, ME, Senterre, G, Castronovo, V, Moreau, L

Biochem. Biophys. Res. Commun. 1995
19782034 Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation

Welford, SM, Giaccia, AJ, Ang, KK, Story, M, Huang, X, Le, QT, Tong, RT, Bennewith, KL, Ding, L

Mol. Cell 2009
17185360 Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA cluster

Casari, G, Sessa, L, Breiling, A, Silvestri, L, Orlando, V, Lavorgna, G

RNA 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RQCD1 [nucleoplasm] (Homo sapiens)
Regulator
atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm] (Homo sapiens)
Active Unit
NCOA3 [nucleoplasm]
EP300 [nucleoplasm]
MLL2,3 complex [nucleoplasm]
RXRA:RARA,G:atRA [nucleoplasm]
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
Regulator
CNOT6:ZNF335 [nucleoplasm] (Homo sapiens)
Inferred From
Hoxa1 gene is transcribed (Mus musculus)
Authored
Rezsohazy, R  (2015-11-15)
May, B  (2014-08-08)
Reviewed
Blasi, F  (2015-05-13)
Created
May, B  (2014-08-09)
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