Reactome | Expression of GLI2 is repressed by GLI3R in the absence of Hh signaling

Expression of GLI2 is repressed by GLI3R in the absence of Hh signaling

Stable Identifier

R-HSA-5617413

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

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Expression of GLI2 is repressed by GLI3R in the absence of Hh signaling

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Expression of the GLI2 gene is repressed in the absence of Hh signaling by GLI3R (Hu et al, 2006). GLI3R may exert its repression activity through the SKI-dependent recruitment of HDACs (Dai et al, 2002).

Literature References

PubMed ID	Title	Journal	Year
12435627	Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3 Dai, P, Shinagawa, T, Nomura, T, Harada, J, Kaul, SC, Wadhwa, R, Khan, MM, Akimaru, H, Sasaki, H, Colmenares, C, Ishii, S	Genes Dev.	2002
16396903	GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis Hu, MC, Mo, R, Bhella, S, Wilson, CW, Chuang, PT, Hui, CC, Rosenblum, ND	Development	2006