Expression of GLI1 is repressed by GLI3R in the absence of Hh signaling

Stable Identifier
R-HSA-5617412
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Expression of GLI1 is repressed by GLI3R in the absence of Hh signaling
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Expression of the GLI1 gene is repressed in the absence of Hh signaling by GLI3R (Hu et al, 2006). GLI3R may exert its repression activity through the SKI-dependent recruitment of HDACs (Dai et al, 2002).
Literature References
PubMed ID Title Journal Year
16396903 GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

Hu, MC, Mo, R, Bhella, S, Wilson, CW, Chuang, PT, Hui, CC, Rosenblum, ND

Development 2006
12435627 Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

Dai, P, Shinagawa, T, Nomura, T, Harada, J, Kaul, SC, Wadhwa, R, Khan, MM, Akimaru, H, Sasaki, H, Colmenares, C, Ishii, S

Genes Dev. 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
GLI1 gene:GLI3R [nucleoplasm] (Homo sapiens)
Active Unit
GLI3R [nucleoplasm]
Authored
Rothfels, K  (2014-07-23)
Reviewed
Liu, Y C  (2014-08-01)
Created
Rothfels, K  (2014-08-07)
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