Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
TYR [melanosome membrane]
Stable Identifier
R-HSA-5617243
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
melanosome membrane
Synonyms
Tyrosinase, TYRO_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in pigmentation (Homo sapiens)
MITF-M-dependent TYR gene expression (Homo sapiens)
TYR [melanosome membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Melanin biosynthesis (Homo sapiens)
DHI and DHICA polymerize forming eumelanin (Homo sapiens)
TYR:2xCu2+ [melanosome membrane] (Homo sapiens)
TYR [melanosome membrane] (Homo sapiens)
Dopa is oxidized to dopaquinone by TYR (Homo sapiens)
TYR:2xCu2+ [melanosome membrane] (Homo sapiens)
TYR [melanosome membrane] (Homo sapiens)
Tyrosinase oxidises tyrosine to dopaquinone (Homo sapiens)
TYR:2xCu2+ [melanosome membrane] (Homo sapiens)
TYR [melanosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14679 TYR
Gene Names
TYR
Chain
signal peptide:1-18, chain:19-529
Reference Genes
BioGPS Gene:7299 TYR
COSMIC (genes):TYR TYR
CTD Gene:7299 TYR
dbSNP Gene:7299 TYR
ENSEMBL:ENSG00000077498 TYR
ENSEMBL_homo_sapiens_GENE:ENSG00000077498.9 TYR
HGNC:12442 TYR
KEGG Gene (Homo sapiens):7299 TYR
Monarch:7299 TYR
NCBI Gene:7299 TYR
OMIM:606933 TYR
UCSC:P14679 TYR
Reference Transcript
RefSeq:NM_000372.4 TYR
Other Identifiers
11730495_s_at
11752891_x_at
1555505_PM_a_at
1555505_a_at
16729865
17120658
206630_PM_at
206630_at
3343835
3343836
3343837
3343838
3343843
3343844
3343856
3343863
3343864
3343865
3372973
3372974
3372979
34155_s_at
38927_i_at
38928_r_at
7299
7942991
7948085
A_14_P107671
A_23_P312505
A_23_P35755
GE80834
GO:0002376
GO:0003824
GO:0004497
GO:0004503
GO:0005507
GO:0005515
GO:0005737
GO:0005764
GO:0005773
GO:0005798
GO:0006520
GO:0006583
GO:0006726
GO:0007601
GO:0008283
GO:0009411
GO:0009637
GO:0016020
GO:0016491
GO:0031410
GO:0033162
GO:0033280
GO:0042438
GO:0042470
GO:0042802
GO:0042803
GO:0043226
GO:0043231
GO:0043473
GO:0046872
GO:0048471
GO:0048538
GO:0048856
GO:0050877
GO:0051591
HMNXSV003008806
ILMN_1788774
M27160_at
PH_hs_0030875
TC11000887.hg
TC11002817.hg
g4507752_3p_at
Participates
as an output of
MITF-M-dependent TYR gene expression (Homo sapiens)
as a component of
TYR:2xCu2+ [melanosome membrane] (Homo sapiens)
Inferred To
TYR [melanosome membrane]
(Bos taurus)
TYR [melanosome membrane]
(Canis familiaris)
TYR [melanosome membrane]
(Dictyostelium discoideum)
TYR [melanosome membrane]
(Gallus gallus)
TYR [melanosome membrane]
(Mus musculus)
TYR [melanosome membrane]
(Sus scrofa)
tyr [melanosome membrane]
(Xenopus tropicalis)
tyr-6 [melanosome membrane]
(Caenorhabditis elegans)
Tyr [melanosome membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_000363.1
ZINC - World Drugs
TYRO_HUMAN
Guide to Pharmacology - Targets
2643
OpenTargets
ENSG00000077498
ZINC - Substances
TYRO_HUMAN
ZINC - Biogenic
TYRO_HUMAN
ZINC target
P14679
PRO
P14679
PDB
7RK7
ZINC - Metabolites
TYRO_HUMAN
HPA
ENSG00000077498-TYR
GeneCards
P14679
Ensembl
ENST00000263321
,
ENSG00000077498
,
ENSP00000263321
Pharos - Targets
P14679
Orphanet
15677
ZINC - Predictions - Purchasable
TYRO_HUMAN
HMDB Protein
HMDBP00087
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51810 GPR143
1
GPR143 [plasma membrane]
(R-HSA-8851292)
0.518
4
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text