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TYR [melanosome membrane]
Stable Identifier
R-HSA-5617243
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
melanosome membrane
Synonyms
Tyrosinase, TYRO_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in pigmentation (Homo sapiens)
MITF-M-dependent TYR gene expression (Homo sapiens)
TYR [melanosome membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Melanin biosynthesis (Homo sapiens)
DHI and DHICA polymerize forming eumelanin (Homo sapiens)
TYR:2xCu2+ [melanosome membrane] (Homo sapiens)
TYR [melanosome membrane] (Homo sapiens)
Dopa is oxidized to dopaquinone by TYR (Homo sapiens)
TYR:2xCu2+ [melanosome membrane] (Homo sapiens)
TYR [melanosome membrane] (Homo sapiens)
Tyrosinase oxidises tyrosine to dopaquinone (Homo sapiens)
TYR:2xCu2+ [melanosome membrane] (Homo sapiens)
TYR [melanosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14679 TYR
Gene Names
TYR
Chain
signal peptide:1-18, chain:19-529
Reference Genes
BioGPS Gene:7299 P146792
COSMIC - genes:TYR TYR
CTD Gene:7299 P146792
dbSNP Gene:7299 TYR
ENSEMBL:ENSG00000077498 TYR
HGNC:12442 P146792
KEGG:hsa:7299 P146792
Monarch:7299 P146792
NCBI Gene:7299 P146792
OMIM:606933 P146792
UCSC:P14679 P146792
Reference Transcript
RefSeq:NM_000372.5 P146792
Participates
as an output of
MITF-M-dependent TYR gene expression (Homo sapiens)
as a component of
TYR:2xCu2+ [melanosome membrane] (Homo sapiens)
Inferred To
TYR [melanosome membrane]
(Bos taurus)
TYR [melanosome membrane]
(Caenorhabditis elegans)
TYR [melanosome membrane]
(Canis familiaris)
TYR [melanosome membrane]
(Dictyostelium discoideum)
TYR [melanosome membrane]
(Gallus gallus)
TYR [melanosome membrane]
(Mus musculus)
TYR [melanosome membrane]
(Sus scrofa)
tyr-2 [melanosome membrane]
(Caenorhabditis elegans)
tyr-5 [melanosome membrane]
(Caenorhabditis elegans)
tyr-4 [melanosome membrane]
(Caenorhabditis elegans)
tyr [melanosome membrane]
(Xenopus tropicalis)
Homologues of TYR [melanosome membrane]
(Caenorhabditis elegans)
Homologues of TYR [melanosome membrane]
(Dictyostelium discoideum)
tyr-6 [melanosome membrane]
(Caenorhabditis elegans)
Tyr [melanosome membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_000363.1
ZINC - World Drugs
TYRO_HUMAN
Guide to Pharmacology - Targets
2643
ENSEMBL
ENSP00000263321
,
ENSG00000077498
,
ENST00000263321
OpenTargets
ENSG00000077498
ZINC - Substances
TYRO_HUMAN
ZINC - Biogenic
TYRO_HUMAN
ZINC target
P14679
PRO
P14679
GlyGen
P14679
PDB
7RK7
ZINC - Metabolites
TYRO_HUMAN
GeneCards
TYR
HPA
ENSG00000077498-TYR
Pharos - Targets
P14679
Orphanet
TYR
ZINC - Predictions - Purchasable
TYRO_HUMAN
HMDB Protein
HMDBP00087
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51810 GPR143
1
GPR143 [plasma membrane]
(R-HSA-8851292)
0.518
4
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