Reactome | B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA

B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA

Stable Identifier

R-HSA-5617143

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

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B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA

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Glycosyltransferase-like protein LARGE2 (GYLTL1B) is a bifunctional glycosyltransferases with both xylosyltransferase and beta-1,3-glucuronyltransferase activities which can form polymeric Xyl-GlcA repeats. GYLTL1B is involved in the physiological function of alpha-dystroglycan (DAG1) which plays a key role in skeletal muscle function and regeneration (Inamori et al. 2013, Wells 2013, Inamori et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
25138275	Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of α-dystroglycan in cells and tissues Inamori, K, Willer, T, Hara, Y, Venzke, D, Anderson, ME, Clarke, NF, Guicheney, P, Bönnemann, CG, Moore, SA, Campbell, KP	J. Biol. Chem.	2014
23125099	Xylosyl- and glucuronyltransferase functions of LARGE in ?-dystroglycan modification are conserved in LARGE2 Inamori, K, Hara, Y, Willer, T, Anderson, ME, Zhu, Z, Yoshida-Moriguchi, T, Campbell, KP	Glycobiology	2013
23329833	The o-mannosylation pathway: glycosyltransferases and proteins implicated in congenital muscular dystrophy Wells, L	J. Biol. Chem.	2013