Complexed PIWIL1 binds pre-piRNA

Stable Identifier
R-HSA-5615682
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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After cleavage by PLD6 at the 5' end, the pre-piRNA is bound by PIWIL1 (HIWI, homolog of MIWI in mouse), likely in a complex with other proteins such as TDRD6 and TDRKH, which interact with methylated arginine residues on PIWIL1 and are required for piRNA biogenesis. Binding by PIWIL1 is believed to be selective for pre-piRNAs that have uracil residues at their 5' ends.

Literature References
PubMed ID Title Journal Year
21465557 Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain

Zeng, L, Zhang, Q, Yan, K, Zhou, MM

Proteins 2011
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