AKR1C3 reduces atRAL to atROL

Stable Identifier
R-HSA-5615668
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The cytosolic aldo-keto reductase 1C3 (AKR1C3) can reduce all-trans-retinal (atRAL) to all-trans-retinol (atROL) (Ruiz et al. 2011). AKR1C3 functions to reduce synthesis of atRA to prevent toxic or teratogenic effects of excess atRA.

Literature References
PubMed ID Title Journal Year
21851338 Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

Ruiz, FX, Porté, S, Gallego, O, Moro, A, Ardèvol, A, Del Río-Espínola, A, Rovira, C, Farrés, J, Parés, X

Biochem. J. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NADP-retinol dehydrogenase activity of AKR1C3 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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